Results 51 to 60 of about 738,250 (296)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Influence of Transverse Reinforcement in Joints and Beam Ends on the Behavior of R/C Beam-Column Subassemblages [PDF]

, 1988
Transverse Reinforcement in Joints and Beam ...
Joh, Osamu, Goto, Yasuaki, Shibata, Takuji   +2 more
core  

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Experimental and theoretical research of strength of compressed reinforced concrete elements with Transverse reinforcement of welded meshes

Будівельні конструкції. Теорія і практика
Transverse reinforcement with welded meshes is used in areas of significant compressive forces, usually in local places, where it is necessary to increase the strength of concrete in axial compression.
Юлій Клімов, Дмитро Сморкалов   +1 more
doaj   +1 more source

Shear strengthening of concrete members with unbonded transverse reinforcement [PDF]

, 2019
This paper examines the behaviour of thick concrete members strengthened in shear with unbonded transverse reinforcement. The retrofitting technique consists of placing unbonded vertical bars with steel end plates or torque controlled expansion end ...
Bastien, Josée, Mitchell, Denis, Fiset, Mathieu   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

SECTIONAL CURVATURE DUCTILTY OF REINFORECD CONCRETE COLUMNS UNDER LARGE INELASTIC DEFORMATION

Journal of Engineering
A mathematical model is developed to express stress-strain relationship of normal-strength concrete confined by transverse reinforcement. The sectional ductility analysis on rectangular reinforced concrete columns is performed under axial load ...
Raad K. Al-Azzawi
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Dog Behaviour - Effect of Delay To Reinforcement [PDF]

, 2012
Dogs were fed dry food as reinforcement and were required to touch a wand with their nose to get that reinforcement. In the first study, half the dogs were given immediate reinforcement, while for the remaining dogs reinforcement was delayed by two ...
Lord, Sarah
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source