Results 61 to 70 of about 738,250 (296)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Strength of reinforced concrete beams, strengthened with additional prestressed transverse reinforcement [PDF]

, 2014
In this article the author gives the results of the experimental and theoretical studies of the strength of the reinforced concrete beams, strengthened with additional pre-stressed transverse ...
Lazouski, Y.
core   +1 more source

Effects of Transverse Reinforcement on Composite Steel Beams with Precast Hoow Core Slabs

, 2002
NoIn composite steel beams with precast hollow core slabs, the amount of transverse reinforcement can have a significant effect on the shear and slip capacity of the mechanical shear connectors.
D. Lam, Lam, Dennis, Nip, T.F., T.F. Nip
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Shear design of reinforced concrete beams with FRP longitudinal and transverse reinforcement [PDF]

Composites Part B: Engineering, 2015
The shear resisting mechanisms of reinforced concrete (RC) beams with longitudinal and transverse FRP reinforcement can be affected by the mechanical properties of the FRP rebars. This paper presents a mechanical model for the prediction of the shear strength of FRP RC beams that takes into account its particularities.
Oller Ibars, Eva, Marí Bernat, Antonio Ricardo, Bairán García, Jesús Miguel, Cladera Bohigas, Antoni   +3 more
openaire   +3 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Behavior of Short Columns Reinforced with Welded Wire Fabric as Transverse Reinforcement under Concentric Loading

Walailak Journal of Science and Technology, 2011
The purpose of this study was to investigate the behavior of concrete columns reinforced by Welded Wire Fabric, WWF, as transverse reinforcement under concentric loading and to compare the results with concrete columns reinforced by round bar as tie ...
Satjapan LEELATANON, Trakool ARAMRAKS
doaj   +1 more source

Research on the Estimation Model of Energy Consumption Capacity for Reinforced Concrete Components with Axial Force

Advances in Civil Engineering, 2023
The research group utilized the estimation model of energy consumption capacity for reinforced concrete components without axial force to assess the energy consumption capacity of 92-reinforced concrete components from the PEER database, which were ...
Yukui Wang, Shijun Yan, Dan Zhang, Zhangqi Hu   +3 more
doaj   +1 more source

Structural Behavior of RC Cylinders Confined with High Strength Transverse Reinforcement

, 2010
The number of high-rise reinforced concrete (RC) buildings is steadily increasing since 1980’s. The use of high strength concrete is indispensible for high-rise RC construction to ensure sufficient strength of the structure.
Cho Hwa Moon, Sang A. Cha, Kil Hee Kim, Sang Woo Kim, Jung Yoon Lee   +4 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source