Results 71 to 80 of about 10,975 (264)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Analysis of Shear Bearing Mechanism and Influencing Factors of MCL-Shaped Composite Dowel Connector

Zhongwai Gonglu
To investigate the bearing mechanism of modified clothoid (MCL)-shaped composite dowel shear connectors and the influence laws of various factors on their shear bearing capacity, the stress states and failure modes of the steel dowel, concrete dowel, and
ZENG Zhuo, ZHOU Baicheng, CHENG Xianjie, CAO Zhengxing, GAO Rongxiong, WANG Zichao   +5 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Shear force and torsion in reinforced concrete beam elements: theoretical analysis based on Brazilian Standard Code ABNT NBR 6118:2007

Revista IBRACON de Estruturas e Materiais
Reinforced concrete beam elements are submitted to applicable loads along their life cycle that cause shear and torsion. These elements may be subject to only shear, pure torsion or both, torsion and shear combined.
R. Barros, J.S. Giongo
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Experimental study on the minimum limit anchorage length and mechanical properties of bent anchorage steel bars in reactor building

Nuclear Engineering and Technology
This study presents a comprehensive investigation into the anchorage performance of bent steel bars embedded in straight segments of reinforced concrete (RC) specimens with high reinforcement ratios, using a prototype nuclear reactor shear wall as the ...
Dayang Wang, Yu Zhang, Yanhu Ding, Mingxin Bai, Zhulin Nie   +4 more
doaj   +1 more source

Numerical Investigation of Reinforced Concrete Columns with Transverse Holes

, 2020
It is not uncommon to provide traverse openings in reinforced concrete (RC) columns for various reasons. The presence of a hole in a reinforced concrete column will disrupt the stress distribution leading it to splitting and failure at an early life. The aim of this study is to numerically investigate the behavior of reinforced concrete columns with ...
openaire   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Structural behavior of concentrically loaded GFRP-RPC circular columns

Al-Qadisiyah Journal for Engineering Science
The behavior of reinforced concrete (RC) members with glass fiber reinforced polymer (GFRP) bars has been the focus of several studies in previous years.
Mohamed Qassim Kadhim, Hassan Falah Hassan   +1 more
doaj   +1 more source