Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss [PDF]
Neural Regeneration ResearchNoise-induced hearing loss is the primary non-genetic factor contributing to auditory dysfunction. However, there are currently no effective pharmacological interventions for patients with noise-induced hearing loss.
Xihang Chen +9 more
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Quercetin and Tranylcypromine Improve Memory, Behavioral Performance, and Cholinergic Function in Male Rats Subjected to Chronic Restraint Stress [PDF]
Brain SciencesBackground/Objectives: Major depressive disorder (MDD) is a debilitating illness, and chronic stress is a contributing factor for depressive symptoms. However, despite intense research, the mechanisms of MDD remain substantially unidentified.
Vitor Bastianello Mostardeiro +14 more
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LSD1 inhibition by tranylcypromine hydrochloride reduces alkali burn-induced corneal neovascularization and ferroptosis by suppressing HIF-1α pathway [PDF]
Frontiers in PharmacologyBackgroundCorneal neovascularization (CNV) is a sight-threatening condition that necessitates epigenetic control. The role of lysine-specific demethylase 1 (LSD1) in CNV remains unclear, despite its established significance in tumor angiogenesis ...
Qian Deng +8 more
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The MAO Inhibitor Tranylcypromine Alters LPS- and Aβ-Mediated Neuroinflammatory Responses in Wild-type Mice and a Mouse Model of AD [PDF]
Cells, 2020 Monoamine oxidase (MAO) has been implicated in neuroinflammation, and therapies targeting MAO are of interest for neurodegenerative diseases. The small-molecule drug tranylcypromine, an inhibitor of MAO, is currently used as an antidepressant and in the ...
HyunHee Park +11 more
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Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 As regioisomers/bioisosteres of 1a, a 4-phenylbenzamide tranylcypromine (TCP) derivative previously disclosed by us, we report here the synthesis and biological evaluation of some (hetero)arylbenzoylamino TCP derivatives 1b-6, in which the 4-phenyl ...
Rossella Fioravanti +13 more
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Tranylcypromine: a red flag for broader reflection [PDF]
Brazilian Journal of PsychiatryLarissa Junkes, Antonio E. Nardi
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Safety of concomitant tranylcypromine treatment during electroconvulsive therapy (ECT) series [PDF]
European Psychiatry, 2022 Introduction Tranylcypromine (TCP), an irreversible monoamine oxidase inhibitor (MAOI), is recommended for difficult-to-treat depression. Besides the requirement of a low-tyramine diet, there are concerns about the safety of TCP treatment during ...
E. Kavakbasi +3 more
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Brazilian Journal of Cardiovascular Surgery, 2019 Objective: In this study, we aimed to examine the effects of amitriptyline, fluoxetine, tranylcypromine and venlafaxine on saphenous vein grafts in coronary artery bypass graft surgeries.
Melek Akinci +6 more
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The Combination of Two Small Molecules Improves Neurological Parameters and Extends the Lifespan of C3H Strain Female Mice [PDF]
Brain and BehaviorObjectives Targeting partial cellular reprogramming pathways through specific small molecule combinations holds promise for lifespan extension in model organisms.
Maria Vedunova +5 more
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Beyond the Brain: Perinatal Exposure of Rats to Serotonin Enhancers Induces Long-Term Changes in the Jejunum and Liver [PDF]
BiomedicinesSerotonin (5-hydroxytryptamine, 5HT) homeostasis is essential for many physiological processes in the central nervous system and peripheral tissues.
Romana Gračan +3 more
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