Results 1 to 10 of about 6,068 (107)
The Combination of Two Small Molecules Improves Neurological Parameters and Extends the Lifespan of C3H Strain Female Mice [PDF]
Brain and Behavior, Volume 15, Issue 6, June 2025.The small molecules RepSox and TCP were investigated for their geroprotective effects in aging C3H mice through intraperitoneal administration. Treatment resulted in improved neurological markers and physical parameters in older mice (16‐20 months), while younger treated mice (10‐13 months) showed increased maximum lifespan compared to controls.
Maria Vedunova +5 more
wiley +2 more sources
Drug‐Related Hypertension: A Disproportionality Analysis Leveraging the FDA Adverse Event Reporting System [PDF]
The Journal of Clinical Hypertension, Volume 27, Issue 3, March 2025.ABSTRACT Hypertension exerts a significant global disease burden, adversely affecting the well‐being of billions. Alarmingly, drug‐related hypertension remains an area that has not been comprehensively investigated. Therefore, this study is designed to utilize the adverse event reports (AERs) from the US Food and Drug Administration's Adverse Event ...
Hao Zhu +3 more
wiley +2 more sources
Dynamics of Cell Fate Decisions during Chemically Induced Multi‐Lineage Trans‐Differentiation at Single‐Cell Level [PDF]
Advanced Science, Volume 12, Issue 17, May 8, 2025.A critical aspect of chromosomal remodeling in small molecule‐induced multilineage trans‐differentiation(iMT) is elucidated. A dynamic atlas spanning over 35 days profiles terminal trans‐differentiated cells, which reverted to a more youthful state. This study reveals parallels between iMT and other cell fate determination processes, emphasizing an ...
Weigao E +13 more
wiley +2 more sources
Angewandte Chemie, EarlyView.We present the first general synthetic strategy for accessing N(CF3)(CF2H) amines, which display a 2000‐fold increase in stability over N‐CF3 amines. The compounds are synthesized through a desulfurization–fluorination of N‐CF3 thioformamides. Abstract With poor metabolic stability being a major cause of failure in drug development, there is a pressing
Gina Wycich +3 more
wiley +2 more sources
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, EarlyView.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar +4 more
wiley +1 more source
Journal of Oral Rehabilitation, Volume 52, Issue 6, Page 923-936, June 2025.ABSTRACT Background Chronic temporomandibular disorder (TMD) pain significantly impairs quality of life and lacks universally effective treatments. Antidepressants, traditionally used for mood disorders, have shown potential in managing chronic pain conditions.
Takara Dei +5 more
wiley +1 more source
Chemistry – A European Journal, Volume 31, Issue 20, April 4, 2025.This review summarizes the synthetic methodologies of the nitro‐substituted Donor‐Acceptor cyclopropanes (NCPs). Particularly from nitroalkenes including the Michael Initiated Ring Closure and the Oxidative Ring Closure of Michael Adducts, from Diazo Compounds bearing Nitro Group, from Nitromethane and its Derivatives; and after Oxidation of ...
Andriani G. Chaidali +2 more
wiley +1 more source
Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges
ChemMedChem, Volume 20, Issue 6, March 15, 2025.The post‐COVID syndromes are strictly dependent from inflammaging and immunosenescence, for which the available treatments, particularly immunotherapy, have limited impact and safety issues. Alternative targets are under validation to disclose, besides anti‐inflammatory drugs, new small molecular entities able to counteract the imbalance of ...
Fabio Francavilla +6 more
wiley +1 more source
HIV Medicine, Volume 26, Issue 3, Page 465-478, March 2025.Abstract Introduction Depressive symptoms are highly prevalent among people with HIV, which can negatively impact HIV‐related outcomes. We explore the cascade of mental healthcare for people with HIV experiencing depressive symptoms. Methods People with HIV who were part of the Pharmacokinetic and clinical Observations in PeoPle over fiftY (POPPY ...
Hajra Okhai +12 more
wiley +1 more source