Results 41 to 50 of about 4,228 (148)

Mono‐ and Bivalent Poly(iso‐butylene)‐Alanines for Drug‐Delivery of Nimodipine and Triamcinolone Acetonide

Macromolecular Rapid Communications, Volume 47, Issue 14, 20 July 2026.
Mono‐ and bivalent‐, alanine‐modified poly‐iso‐butylenes, folding into beta‐sheets, were prepared by living carbocationic polymerization and subsequent endgroup modification. These PIB‐conjugates are useful as solid polymers for the drug release of triamcinolone and nimodipine. ABSTRACT Poly‐iso‐butylene (PIB) is a well known biocompatible polymer with
Philipp S. Hilgeroth, Julius F. Butter, Wolfgang H. Binder   +2 more
wiley   +1 more source

Inhibitory effects of agmatine on monoamine oxidase (MAO) activity: Reconciling the discrepancies

The EuroBiotech Journal, 2018
Agmatine has been functionally characterized as an important hormone and co-neurotransmitter in mammals. Given its ability in binding Imidazoline sites, a regolatory site of monoaminoxydase, it has been suggested to be involved in many neurological ...
Mancinelli Loretta, Ragonese Francesco, Cataldi Samuela, Ceccarini Maria Rachele, Iannitti Rossana G., Arcuri Cataldo, Fioretti Bernard   +6 more
doaj   +1 more source

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, Volume 2, Issue 2, June 2026.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

Suppression of Invasion and Metastasis of Triple-Negative Breast Cancer Lines by Pharmacological or Genetic Inhibition of Slug Activity

Neoplasia: An International Journal for Oncology Research, 2014
Most triple-negative breast cancers (TNBCs) exhibit gene expression patterns associated with epithelial-to-mesenchymal transition (EMT), a feature that correlates with a propensity for metastatic spread.
Giovanna Ferrari-Amorotti, Claudia Chiodoni, Fei Shen, Sara Cattelani, Angela Rachele Soliera, Gloria Manzotti, Giulia Grisendi, Massimo Dominici, Francesco Rivasi, Mario Paolo Colombo, Alessandro Fatatis, Bruno Calabretta   +11 more
doaj   +1 more source

The Viloxazine Paradox: A Noradrenergic Agent's Journey From Antidepressant Obscurity to ADHD Precision Therapy

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
Viloxazine, a serotonin–norepinephrine modulating agent, has been repurposed from an antidepressant to a novel non‐stimulant for ADHD. Its multimodal mechanism and Phase II/III trials demonstrate clinically meaningful symptom reduction with a distinct safety and interaction profile, offering an alternative for patients who cannot tolerate stimulants ...
Ghaith K. Mansour, Sabry Babiker H. Sayed, Sajjad Ghanim Al‐Badri, Mohammed Gamaleldin Abdulrahim Abdalla, Dina Essam Abo‐elnour   +4 more
wiley   +1 more source

The Histone‐Lysine N‐Methyltransferase (KMT2) Family in Health and Disease

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract clarifies KMT2 family dysregulation and disease associations: its member mutations cause epigenetic imbalance and abnormal cell development; Menin/WDR5 inhibitors and other targeted therapies block aberrant epigenetic transcriptional programs, and combined synergistic therapies boost therapeutic efficacy.
Qiu Wang, Zunjie Bo, Ya Zhang, Yun Chen, Zhiyu Wang, Shuangmei Tong, Ajing Xu, Jian Zhang, Yan Liu   +8 more
wiley   +1 more source

Scaffolding LSD1 Inhibitors Impair NK Cell Metabolism and Cytotoxic Function Through Depletion of Glutathione

Frontiers in Immunology, 2020
Cell therapies such as chimeric-antigen receptor (CAR) T-cells and NK cells are cutting-edge methods for treating cancer and other diseases. There is high interest in optimizing drug treatment regimens to best work together with emerging cell therapies ...
Cavan P. Bailey, Cavan P. Bailey, Cavan P. Bailey, Mary Figueroa, Mary Figueroa, Mary Figueroa, Achintyan Gangadharan, Dean A. Lee, Joya Chandra, Joya Chandra, Joya Chandra   +10 more
doaj   +1 more source

A Tutorial on Optimal Dynamic Treatment Regimes

Statistics in Medicine, Volume 45, Issue 3-5, February 2026.
ABSTRACT A dynamic treatment regime (DTR) is a sequence of treatment decision rules tailored to an individual's evolving status over time. In precision medicine, much focus has been placed on finding an optimal DTR which, if followed by everyone in the population, would yield the best outcome on average; and extensive investigations have been conducted
Chunyu Wang, Brian D. M. Tom
wiley   +1 more source

Evaluation of the Effects of Mitragyna speciosa Alkaloid Extract on Cytochrome P450 Enzymes Using a High Throughput Assay

Molecules, 2011
The extract from Mitragyna speciosa has been widely used as an opium substitute, mainly due to its morphine-like pharmacological effects. This study investigated the effects of M. speciosa alkaloid extract (MSE) on human recombinant cytochrome P450 (CYP)
Raja Elina Raja Aziddin, Zahurin Mohamed, Umarani Subramaniam, Murali Ramachandra, Zamri Chik, Wai Mun Kong   +5 more
doaj   +1 more source

CEBPA mutants down-regulate AML cell susceptibility to NK-mediated lysis by disruption of the expression of NKG2D ligands, which can be restored by LSD1 inhibition

OncoImmunology, 2022
NK group 2, member D (NKG2D) is one of the most critical activating receptors expressed by natural killer (NK) cells. There is growing evidence that acute myeloid leukemia (AML) cells may evade NK cell-mediated cell lysis by expressing low or no ligands ...
Meng Liu, Mengbao Du, Jian Yu, Zijun Qian, Yang Gao, Wenjue Pan, Xiujie Zhao, Mowang Wang, Huimin Li, Jiaqi Zheng, Qianshuo Huang, Li-Mengmeng Wang, Haowen Xiao   +12 more
doaj   +1 more source