Results 61 to 70 of about 4,228 (148)

Dynamics of Cell Fate Decisions during Chemically Induced Multi‐Lineage Trans‐Differentiation at Single‐Cell Level

Advanced Science
Cell trans‐differentiation offers a powerful means to manipulate cell identities. By exposing cells to a combination of small molecules (SMs), cell trans‐differentiation can be induced in a simple and cost‐effective manner. However, a comprehensive atlas
Weigao E, Lijiang Fei, Jingjing Wang, Xinru Wang, Renying Wang, Xueyi Wang, Peijing Zhang, Jianhui Chen, Junqing Wu, Mengmeng Jiang, Daosheng Huang, Danmei Jia, Guoji Guo, Xiaoping Han   +13 more
doaj   +1 more source

MAO inhibitors for treatment-resistant depression: Bringing an updated perspective on pioneering drugs

Pharmacological Research
In the 1950s, monoamine oxidase inhibitors transformed the pharmacological treatment of mental disorders as the first class of antidepressant drugs.
Larissa Junkes, Laiana A. Quagliato, Jose C. Appolinario, Richard I. Shader, Antonio E. Nardi   +4 more
doaj   +1 more source

Identification and Evaluation of Olive Phenolics in the Context of Amine Oxidase Enzyme Inhibition and Depression: In Silico Modelling and In Vitro Validation

Molecules
The Mediterranean diet well known for its beneficial health effects, including mood enhancement, is characterised by the relatively high consumption of extra virgin olive oil (EVOO), which is rich in bioactive phenolic compounds.
Tom C. Karagiannis, Katherine Ververis, Julia J. Liang, Eleni Pitsillou, Siyao Liu, Sarah M. Bresnehan, Vivian Xu, Stevano J. Wijoyo, Xiaofei Duan, Ken Ng, Andrew Hung, Erik Goebel, Assam El-Osta   +12 more
doaj   +1 more source

Tranylcypromine and Convulsions [PDF]

BMJ, 1963
openaire   +2 more sources

NLRP3 inflammasome and hearing loss: from mechanisms to therapies

Journal of Neuroinflammation
The NLRP3 inflammasome, a key component of the innate immune system, has emerged as a central mediator of inflammation-driven sensorineural hearing loss (SNHL).
Silvia Murillo-Cuesta, Elena Seoane, Blanca Cervantes, Jose Manuel Zubeldia, Isabel Varela-Nieto   +4 more
doaj   +1 more source

Serotonin syndrome masquerading as status epilepticus following ingestion of tranylcypromine and clomipramine and L-tryptophan: A case report

Annals of Indian Academy of Neurology, 2022
Swetha Ambarapu, Kedar Tilwe, Rahul A Pandit, Bhagyashri V Gaikwad, Haresh M Meshram, Jitendra Choudhary, Rima Chaudhari   +6 more
doaj   +1 more source

Computational study of chalcone-cyanopyrimidine hybrids as LSD1 inhibitors: Assessing the influence of FAD on binding affinity and inhibition. [PDF]

Biochem Biophys Rep
Saifullah MK, Gupta A, Parveen D, Azam F, Alam MM, Akhter M, Parvez S, Maksud N, Azeez N, Shaquiquzzaman M.   +9 more
europepmc   +1 more source

Leveraging topological indices and machine learning for advanced prediction of antidepressant drug properties. [PDF]

Sci Rep
Zhang G, Noureen S, Azam S, Abdalla MEM, Dafaalla ME, Aslam A, Tola KA.   +6 more
europepmc   +1 more source

Sensitization of Non-M3 Acute Myeloid Leukemia Blasts to All-Trans Retinoic Acid by the LSD1 Inhibitor Tranylcypromine: TRANSATRA Phase I Study. [PDF]

Eur J Haematol
Kruszewski M, Schmoor C, Berg T, Rehman UU, Schittenhelm M, Götze K, Kündgen A, Pabst C, Ma T, Frey A, Stomper J, Pfeifer D, Metzger E, Jung J, Moschallski K, Thomas J, Bug G, Duyster J, Jung M, Schüle R, Wäsch R, Grishina O, Lübbert M.   +22 more
europepmc   +1 more source

Decoding the Snail transcriptional network: its role in cancer progression and therapy. [PDF]

Biol Direct
Parfenyev SE, Nazarov AN, Daks AA, Fedorova OA, Barlev NA, Shuvalov OY.   +5 more
europepmc   +1 more source