Results 51 to 60 of about 4,228 (148)
Journal of Lipid Research, 2020 Geranylgeranoic acid (GGA) originally was identified in some animals and has been developed as an agent for preventing second primary hepatoma. We previously have also identified GGA as an acyclic diterpenoid in some medicinal herbs.
Yuki Tabata, Yoshihiro Shidoji
doaj +1 more source
LSD1 inhibition yields functional insulin-producing cells from human embryonic stem cells
Stem Cell Research & Therapy, 2020 Background Human embryonic stem cells represent a potentially unlimited source of insulin-producing cells for diabetes therapy. While tremendous progress has been made in directed differentiation of human embryonic stem cells into IPCs in vitro, the ...
Fei He +7 more
doaj +1 more source
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan +6 more
wiley +1 more source
TRANYLCYPROMINE AND CHEESE [PDF]
The Lancet, 1963 A M, ASATOOR, A J, LEVI, M D, MILNE
openaire +4 more sources
Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 1, January 2026.ABSTRACT Modafinil is approved for excessive daytime sleepiness in narcolepsy, obstructive sleep apnoea (OSA), and shift work sleep disorder (SWSD), but its widespread off‐label use raises safety concerns. We evaluated the risk of adverse events (AEs) associated with both labelled and off‐label use of modafinil.
Jaehee Jung +5 more
wiley +1 more source
Reverse Takotsubo Cardiomyopathy Induced By Tyramine Reaction
Case Reports in Cardiology, Volume 2026, Issue 1, 2026.Background Reverse takotsubo cardiomyopathy is a variant of takotsubo cardiomyopathy (TC) where the basal and midventricular segments of the left ventricle are akinetic. TC is typically precipitated by emotional stress; however, the exact pathogenesis of the disease remains unclear.
Robert Holley +3 more
wiley +1 more source
Unravelling the target landscape of tranylcypromines for new drug discovery
Acta Pharmaceutica Sinica BMolecular editing around privileged scaffolds, also known as periphery editing, is a commonly used strategy in contemporary drug discovery and development.
Yihui Song, Junbiao Chang, Bin Yu
doaj +1 more source
Forced intracellular degradation of xenoantigens as a modality for cell-based cancer immunotherapy
iScienceSummary: Given recent leverage of mesenchymal stromal cells (MSCs) as a potent vaccination platform, we investigated whether forced degradation of an expressed experimental antigen fused to small degron sequences could prime potent antitumoral responses.
Jean Pierre Bikorimana +10 more
doaj +1 more source
MoleculesLysine-specific demethylase 1 (LSD1/KDM1A) has emerged as a promising therapeutic target for treating various cancers (such as breast cancer, liver cancer, etc.) and other diseases (blood diseases, cardiovascular diseases, etc.), owing to its observed ...
Di Han +10 more
doaj +1 more source