Results 21 to 30 of about 4,228 (148)
Repurposing existing drugs: identification of SARS-CoV-2 3C-like protease inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19). Since its emergence, the COVID-19 pandemic has not only distressed medical services but also caused economic upheavals, marking urgent ...
Wei-Chung Chiou +6 more
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LSD1 inhibitors for cancer treatment: Focus on multi-target agents and compounds in clinical trials
Frontiers in Pharmacology, 2023 Histone lysine-specific demethylase 1 (LSD1/KDM1A) was first identified in 2004 as an epigenetic enzyme able to demethylate specific lysine residues of histone H3, namely H3K4me1/2 and H3K9me1/2, using FAD as the cofactor.
Beatrice Noce +4 more
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Hepatic Oncology, 2019 Aim: Histone-modifiable lysine-specific demethylase-1 (LSD1/KDM1A) is an oncoprotein upregulated in cancers, including hepatoma. We previously reported that the hepatoma-preventive geranylgeranoic acid (GGA) inhibits KDM1A at the same IC50 as that of the
Suemi Yabuta, Yoshihiro Shidoji
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Acta Obstetricia et Gynecologica Scandinavica, 1997 Background. The effect of hydrogen peroxide (H2O2) on vascular tone in the human umbilical artery was investigated to determine the mechanism of vasospasm in preeclampsia. Methods.
Yuji Okatani +2 more
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Journal of Pharmacy & Pharmaceutical Sciences, 2008 PURPOSE. To compare phenelzine (PLZ), an antidepressant drug with anxiolytic properties which inhibits monoamine oxidase (MAO) but also elevates rat brain levels of the amino acids ?-aminobutyric acid (GABA) and alanine (ALA), with vigabatrin (VIG ...
Kathryn G. Todd, Glen B. Baker
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Pharmacological inhibition of LSD1 activity blocks REST-dependent medulloblastoma cell migration
Cell Communication and Signaling, 2018 Background Medulloblastoma (MB) is the most common malignant brain tumor in children. Current problems in the clinic include metastasis, recurrence, and treatment-related sequelae that highlight the need for targeted therapies.
Keri Callegari +3 more
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Anti-cancer effect of LINC00478 in bladder cancer correlates with KDM1A-dependent MMP9 demethylation
Cell Death Discovery, 2022 Accumulating evidence has highlighted the important roles of long intergenic non-coding RNAs (lincRNAs) during cancer progression. However, the involvement of LINC00478 in bladder cancer remains largely unclear.
Han-Jie Yang, Tian Liu, Yang Xiong
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Metabolites, 2022 Geranylgeranoic acid (GGA), developed as a preventive agent against second primary hepatoma, has been reported to be biosynthesized via the mevalonate pathway in human hepatoma-derived cells.
Yuki Tabata, Yoshihiro Shidoji
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Neurogenic Stuttering and Lateralized Motor Deficits Induced by Tranylcypromine
Behavioural Neurology, 1994 A case of neurogenic stuttering induced by the monoamine oxidase inhibitor tranylcypromine is described. The association of neurogenic stuttering with acquired lateralized motor deficits in the patient described is discussed with reference to current ...
J. D. Duffy
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Borylcyclopropanes: Synthetic Strategies and Applications
Angewandte Chemie International Edition, EarlyView.Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley +1 more source