Tranylcypromine: a promising repurposed drug against Leishmaniases [PDF]
Frontiers in MicrobiologyLeishmaniases remain a major global health challenge due to limited and often toxic therapeutic options. Recent advances in artificial intelligence have enabled the identification of novel antileishmanial candidates through drug repurposing approaches ...
Rafeh Oualha +4 more
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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss [PDF]
Neural Regeneration ResearchNoise-induced hearing loss is the primary non-genetic factor contributing to auditory dysfunction. However, there are currently no effective pharmacological interventions for patients with noise-induced hearing loss.
Xihang Chen +9 more
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In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation [PDF]
Aging Cell, Volume 25, Issue 2, February 2026.Partial chemical reprogramming significantly increases mitochondrial interaction networks, affects mitochondrial morphology, speeds up mitochondrial movement dynamics, increases mitochondrial transmembrane potential, and induces TCA cycle stress. These changes in mitochondrial function contribute to lipid droplet accumulation, acute kidney injury, and ...
Wayne Mitchell +9 more
wiley +2 more sources
Quercetin and Tranylcypromine Improve Memory, Behavioral Performance, and Cholinergic Function in Male Rats Subjected to Chronic Restraint Stress [PDF]
Brain SciencesBackground/Objectives: Major depressive disorder (MDD) is a debilitating illness, and chronic stress is a contributing factor for depressive symptoms. However, despite intense research, the mechanisms of MDD remain substantially unidentified.
Vitor Bastianello Mostardeiro +14 more
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The Combination of Two Small Molecules Improves Neurological Parameters and Extends the Lifespan of C3H Strain Female Mice [PDF]
Brain and BehaviorObjectives Targeting partial cellular reprogramming pathways through specific small molecule combinations holds promise for lifespan extension in model organisms.
Maria Vedunova +5 more
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Characterizing treatment initiation with central nervous system–active polypharmacy among adults with dementia [PDF]
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION Central nervous system (CNS) –active polypharmacy, defined as concurrent use of antidepressants, antipsychotics, anti‐seizure medications, benzodiazepines, nonbenzodiazepine benzodiazepine receptor agonists, opioids, or skeletal muscle relaxants for ≥ 31 consecutive days, poses significant risks patients with dementia.
Donovan T. Maust +9 more
wiley +2 more sources
LSD1 inhibition by tranylcypromine hydrochloride reduces alkali burn-induced corneal neovascularization and ferroptosis by suppressing HIF-1α pathway [PDF]
Frontiers in PharmacologyBackgroundCorneal neovascularization (CNV) is a sight-threatening condition that necessitates epigenetic control. The role of lysine-specific demethylase 1 (LSD1) in CNV remains unclear, despite its established significance in tumor angiogenesis ...
Qian Deng +8 more
doaj +2 more sources
Tranylcypromine: a red flag for broader reflection [PDF]
Brazilian Journal of PsychiatryLarissa Junkes, Antonio E. Nardi
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Cells, 2022 Mesenchymal stromal cells (MSCs) are commonly known for their immune-suppressive abilities. However, our group provided evidence that it is possible to convert MSCs into potent antigen presenting cells (APCs) using either genetic engineering or ...
Fatemeh Mardani +7 more
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Safety of concomitant tranylcypromine treatment during electroconvulsive therapy (ECT) series
European Psychiatry, 2022 Introduction Tranylcypromine (TCP), an irreversible monoamine oxidase inhibitor (MAOI), is recommended for difficult-to-treat depression. Besides the requirement of a low-tyramine diet, there are concerns about the safety of TCP treatment during ...
E. Kavakbasi +3 more
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