Results 81 to 90 of about 7,161 (183)

Hepatic monoamine oxidase B is involved in endogenous geranylgeranoic acid synthesis in mammalian liver cells[S]

Journal of Lipid Research, 2020
Geranylgeranoic acid (GGA) originally was identified in some animals and has been developed as an agent for preventing second primary hepatoma. We previously have also identified GGA as an acyclic diterpenoid in some medicinal herbs.
Yuki Tabata, Yoshihiro Shidoji
doaj   +1 more source

RIG‐I‐Inducing Small Molecules Potently Inhibit HMA‐Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Advanced Science, Volume 12, Issue 36, September 25, 2025.
This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen, Jiaqi Wu, Yuntong Li, Jiayu Huang, Xiangqin Weng, Jiale Wu, Shujun Xiao, Huaxin Song, Zhengyuan Wang, Ni Yan, Fangfang Shi, Derun Zheng, Kai Tan, Hesong Zhang, Jingyi Cui, Wen Wu, Wei Wu, Sujiang Zhang, Min Lu   +18 more
wiley   +1 more source

EFFECT OF PERINATAL CHANGES IN SEROTONIN METABOLISM ON THE DEVELOPMENT AND BEHAVIOUR OF RAT PUPS [PDF]

, 2015
Serotonin (5HT) je biogeni amin prisutan u mozgu (središnji odjeljak) i tjelesnim tkivima (periferni odjeljak) gdje ima različite fiziološke uloge. U ovom radu ispitali smo utjecaj perinatalnog povećanja koncentracije serotonina na stopu preživljenja ...
Merkler, Mirna
core   +1 more source

Defining Treatment‐Resistant Bipolar Depression: Recommendations From the ISBD Task Force

Bipolar Disorders, Volume 27, Issue 6, Page 411-423, September 2025.
ABSTRACT Objective Despite the availability of approved treatments, a substantial proportion of patients with bipolar disorder experience treatment‐resistant bipolar depression (TRBD), characterized by persistent depressive symptoms unresponsive to standard therapies. However, a universally accepted definition of TRBD is lacking.
Eduard Vieta, Roger S. McIntyre, Trisha Suppes, Tamsyn E. Van Rheenen, Balwinder Singh, Kamilla Woznica Miskowiak, Allan H. Young, Lakshmi N. Yatham, Kyooseob Ha, Michael Berk, Holly A. Swartz, Chantal Henry, Maja Pantovic Stefanovic, Gerard Anmella Diaz, Aysegul Ozerdem, Wiesław J. Cubała, Diego Hidalgo‐Mazzei, Mauricio Tohen, Isabella Pacchiarotti, Paula Villela Nunes, Carlos Lopez‐Jaramillo, Ana Gonzalez‐Pinto, Paolo Brambilla, Robert Post, Jair C. Soares, Michael Bauer, Ana C. Andreazza, Xavier Justes Fradera, Montserrat Cosials‐Lopez, Giovanna Fico   +29 more
wiley   +1 more source

Preliminary prediction of individual response to electroconvulsive therapy using whole-brain functional magnetic resonance imaging data. [PDF]

, 2020
Electroconvulsive therapy (ECT) works rapidly and has been widely used to treat depressive disorders (DEP). However, identifying biomarkers predictive of response to ECT remains a priority to individually tailor treatment and understand treatment ...
Abbott, Christopher C, Calhoun, Vince D, Espinoza, Randall, Jiang, Rongtao, Jones, Tom, Narr, Katherine L, Qi, Shile, Sui, Jing, Sun, Hailun, Upston, Joel, Wade, Benjamin Sc   +10 more
core   +1 more source

Differential expression of exosomal microRNAs in prefrontal cortices of schizophrenia and bipolar disorder patients [PDF]

, 2013
Exosomes are cellular secretory vesicles containing microRNAs (miRNAs). Once secreted, exosomes are able to attach to recipient cells and release miRNAs potentially modulating the function of the recipient cell.
Banigan, Meredith G., Cabral, Howard, Cagsal-Getkin, Ozge, Costa, Joan, Delalle, Ivana, Kao, Patricia F., Kozubek, James A., Medina, Juan, Schmitt, Andrea, Schneider, Anja, Vanderburg, Charles R., Winslow, Ashley R.   +11 more
core   +4 more sources

Unravelling the target landscape of tranylcypromines for new drug discovery

Acta Pharmaceutica Sinica B
Molecular editing around privileged scaffolds, also known as periphery editing, is a commonly used strategy in contemporary drug discovery and development.
Yihui Song, Junbiao Chang, Bin Yu
doaj   +1 more source

RNA Epigenetics in Cancer: Current Knowledge and Therapeutic Implications

MedComm, Volume 6, Issue 8, August 2025.
RNA epigenetics regulates cancer through RNA modifications, splicing, transport, and translation. Key components include m⁶A writers, splicing factors, RBPs, and nuclear export machinery. Aberrant RNA metabolism drives tumor progression and immune evasion.
Shanhe Huang, Zonglin Li, Weilong Lin, Ruihui Xie, Hai Huang   +4 more
wiley   +1 more source

Forced intracellular degradation of xenoantigens as a modality for cell-based cancer immunotherapy

iScience
Summary: Given recent leverage of mesenchymal stromal cells (MSCs) as a potent vaccination platform, we investigated whether forced degradation of an expressed experimental antigen fused to small degron sequences could prime potent antitumoral responses.
Jean Pierre Bikorimana, Roudy Farah, Jamilah Abusarah, Gabrielle Arona Mandl, Mohamed Ali Erregragui, Marina Pereira Gonçalves, Sebastien Talbot, Perla Matar, Malak Lahrichi, Nehme El-Hachem, Moutih Rafei   +10 more
doaj   +1 more source

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation [PDF]

, 2010
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molecules will alter complex behaviors. We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior ...
Arvanites, Anthony, Haggarty, Stephen J., Jang, Sumin, Kokel, David, Lam, Kelvin, Peterson, Randall T., Prober, David A., Rihel, Jason, Rubin, Lee L., Schier, Alexander F., Zimmerman, Steven   +10 more
core   +1 more source