Results 141 to 150 of about 70,621 (279)
Factors Affecting Long-Term Safety of Trastuzumab in Patients with Early HER2-Positive Breast Cancer
, 2014 Boekhout AH Werkhoven
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Self‐Immolative Systems in Diagnostic and Therapeutic Applications
ChemMedChem, Volume 21, Issue 5, 13 March 2026.Self‐Immolative Systems enable the precise, residue‐free release of active molecules, drugs, probes, or sensors, via cyclization or elimination, triggered by specific stimuli. Their versatility drives advances in drug delivery, diagnostics, nanotechnology, materials chemistry, and biosensing, offering chemists control over molecular activation and ...
Windbedema Prisca Ouédraogo +2 more
wiley +1 more source
Resistance to HER2-targeted therapy
Research in Molecular Medicine, 2013 Production and approval of trastuzumab (Herceptin®) for the treatment of metastatic breast cancer (MBC) was a millstone in antibody-based targeted therapy in the cancer treatment.
Reza Valadan +3 more
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69P TGFBI promoter methylation validation as an epigenetic biomarker for trastuzumab resistance in HER2+ breast cancer patients cohort [PDF]
, 2020 Helena Pla +8 more
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Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.Der dynamische Austausch von Bindemolekülen (Dynamic Binder Exchange; DyBE) nutzt transiente Binde–Zielprotein‐Interaktionen, um die Markierungseffizienz in der superauflösenden Mikroskopie um das 15‐Fache zu steigern. DyBE kartiert die Organisation von Rezeptor‐Tyrosinkinasen (RTKs), einschließlich HER2‐Homodimere und EGFR–HER2‐Heterodimere, auf der ...
Clemens Steinek +5 more
wiley +1 more source
Pathologic Complete Response Rates After Neoadjuvant Pertuzumab and Trastuzumab with Chemotherapy in Early Stage HER2-Positive Breast Cancer - Increasing Rates of Breast Conserving Surgery: A Real-World Experience [PDF]
, 2021 Katalin Boér +8 more
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Dynamic Binder Exchange Improves Protein Labeling Efficiency in DNA‐PAINT up to 15‐Fold
Angewandte Chemie International Edition, Volume 65, Issue 11, 9 March 2026.Dynamic Binder Exchange (DyBE) leverages transient binder–target interactions to enhance labeling efficiency by up to 15‐fold in super‐resolution microscopy. DyBE maps nanoscale receptor tyrosine kinase (RTK) assemblies, including HER2 homodimers and EGFR–HER2 heterodimers, advancing single‐protein spatial proteomics.
Clemens Steinek +5 more
wiley +1 more source
MARPLE: A Proximity‐Triggered CRISPR‐Cas13 Platform for Ultrasensitive Antibody Detection
Advanced Science, Volume 13, Issue 13, 3 March 2026.MARPLE is a modular CRISPR‐Cas13 immunoassay that uses antibody‐induced proximity to trigger a toehold‐exchange reaction, releasing an RNA activator for Cas13. This one‐pot, isothermal architecture enables ultrasensitive (femtomolar) and highly specific detection of diverse antibodies, including therapeutic, pathogen‐specific, and cancer‐associated ...
Elena Spezzani +6 more
wiley +1 more source