Results 71 to 80 of about 344,176 (305)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Comprehensive meta-analysis of emergency trauma outcomes: trends, interventions, and survival rates

Frontiers in Public Health
BackgroundTrauma remains one of the leading global health challenges, with morbidity and mortality disproportionately affecting low- and middle-income countries (LMICs). While high-income nations have reported improved outcomes through the implementation
Aiming Li, Qiaoyan Feng, Ye Zhao, Xianhuan Zhang, Weijie Jiang   +4 more
doaj   +1 more source

Trauma Care in Georgia Building a Better System [PDF]

, 2004
A focus on the need for Georgia to build a coordinated, regionalized, and accountable trauma ...
Holly Avey
core  

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Trauma center level and postoperative mortality: a nationwide cohort study from South Korea

Scientific Reports
Trauma center designation may influence surgical outcomes, but evidence from Asian trauma systems remains limited. This study examined the association between trauma center level and postoperative mortality following trauma surgery in South Korea.
Tak Kyu Oh, In-Ae Song, Young-Tae Jeon
doaj   +1 more source

Computerized alcohol screening identified more at-risk drinkers in a level 2 than a level 1 trauma center

BMC Public Health, 2017
Background Alcohol abuse is recognized as a significant contributor to injury. It is therefore essential that trauma centers implement screening and brief intervention (SBI) to identify patients who are problem drinkers.
Ghasem Imani, Cristobal Barrios, Craig L. Anderson, Maryam Hosseini Farahabadi, Faried Banimahd, Bharath Chakravarthy, Wirachin Hoonpongsimanont, Christopher E. McCoy, Georginne Mercado, Babak Farivar, Jacqueline K. Pham, Shahram Lotfipour   +11 more
doaj   +1 more source

Trauma-Associated Tinnitus: Audiological, Demographic and Clinical Characteristics [PDF]

, 2012
Background: Tinnitus can result from different etiologies. Frequently, patients report the development of tinnitus after traumatic injuries. However, to which extent this specific etiologic factor plays a role for the phenomenology of tinnitus is still ...
Azevedo, Andréia, Binetti, Ana Carolina, Coelho, Claudia, de Ridder, Dirk, Elgoyhen, Ana Belen, Figueiredo, Ricardo, Kleinjung, Tobias, Koller, Michael, Kreuzer, Peter M., Landgrebe, Michael, Langguth, Berthold, Lehner, Astrid, Mohr, Markus, Poeppl, Timm B., Rates, Marcelo, Schecklmann, Martin, Staudinger, Susanne, van de Heyning, Paul, Vanneste, Sven, Vielsmeier, Veronika, Zeman, Florian   +20 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Moving Toward Healing: Trauma and Violence and Boys and Young Men of Color [PDF]

, 2016
The purpose of this brief is to highlight the great burden that trauma, violence, adversity, and the social determinants  of health impose on the health of boys and men of color. To protect BYMOC from the potential harm inflicted on  them—and to mobilize
John Rich
core