Results 81 to 90 of about 350,171 (303)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Trauma center level and postoperative mortality: a nationwide cohort study from South Korea

Scientific Reports
Trauma center designation may influence surgical outcomes, but evidence from Asian trauma systems remains limited. This study examined the association between trauma center level and postoperative mortality following trauma surgery in South Korea.
Tak Kyu Oh, In-Ae Song, Young-Tae Jeon
doaj   +1 more source

Comprehensive meta-analysis of emergency trauma outcomes: trends, interventions, and survival rates

Frontiers in Public Health
BackgroundTrauma remains one of the leading global health challenges, with morbidity and mortality disproportionately affecting low- and middle-income countries (LMICs). While high-income nations have reported improved outcomes through the implementation
Aiming Li, Qiaoyan Feng, Ye Zhao, Xianhuan Zhang, Weijie Jiang   +4 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Computerized alcohol screening identified more at-risk drinkers in a level 2 than a level 1 trauma center

BMC Public Health, 2017
Background Alcohol abuse is recognized as a significant contributor to injury. It is therefore essential that trauma centers implement screening and brief intervention (SBI) to identify patients who are problem drinkers.
Ghasem Imani, Cristobal Barrios, Craig L. Anderson, Maryam Hosseini Farahabadi, Faried Banimahd, Bharath Chakravarthy, Wirachin Hoonpongsimanont, Christopher E. McCoy, Georginne Mercado, Babak Farivar, Jacqueline K. Pham, Shahram Lotfipour   +11 more
doaj   +1 more source

Addressing Childhood Adversity and Social Determinants inPediatric Primary Care:Recommendations for New Hampshire [PDF]

, 2018
Research has clearly demonstrated the significant short- and long-term impacts of adverse childhood experiences (ACEs) and the social determinants of health (SDOH) on child health and well-being.1 Identifying and addressing ACEs and SDOH will require a ...
Corvini, Marguerite, Cox, Katherine, O’Neil, Molly, Ryer, Jeanne, EdD, Tutko, Holly Deblois   +4 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Set in Stone: Building America's New Generation of Arts Facilities, 1994-2008 [PDF]

, 2012
In 2007, just before the domestic economy experienced a major trauma, the Cultural Policy Center at the Harris School and NORC at the University of Chicago launched a national study of cultural building in the United States.
Anastasia Kolendo, Bruce A. Seaman, D. Carroll Joynes, Joanna Woronkowica, Norman Bradburn, Peter Frumkin, Robert Gertner   +6 more
core  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source