Results 71 to 80 of about 1,399,008 (302)

Emotion regulation mediates the effect of childhood trauma on depression [PDF]

, 2016
Background Childhood trauma increases the risks of both depression and dysfunctional emotion regulation, which is a factor that has been strongly linked to depression. Because of these demonstrated relationships, it can be hypothesized that dysfunctional
Ebert, David D., Berking, Matthias, Trauma and Grief, Bockting, Claudi, Bockting, C. L. H., Hopfinger, Lisa, Leerstoel Bockting, Bockting, Claudi L.H., Ebert, David D.; id_orcid   +8 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

American Association for the Surgery of Trauma Prevention Committee review: Family Justice Centers—a not-so-novel, but unknown gem

Trauma Surgery & Acute Care Open, 2021
The American College of Surgeons Committee on Trauma requires that trauma centers demonstrate adequate financial support for an injury prevention program as part of the verification process.
Deborah A Kuhls, Kazuhide Matsushima, Ronald Stewart, Tracey Dechert, Stephanie Bonne, Thomas K Duncan, Kimberly Joseph, Sharven Taghavi   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Trauma center proliferation in the United States: concerns and potential solutions

OTA International
. There has been an increase in the number of Level I and II trauma centers across the United States in the past few decades. However, data suggest that access to trauma care remains poor in rural areas of the country, while in many urban areas, trauma ...
Niloofar Dehghan, MD, Lisa K. Cannada, MD, Ashraf N. El Naga, MD, Anna Miller, MD, Dan Schlatterer, DO, on behalf of the Orthopaedic Trauma Association Health Policy Committee   +5 more
doaj   +1 more source

Provision of trauma teams in Scotland: a national survey [PDF]

, 2010
<b>Background and Aims:</b> Trauma is still the leading cause of mortality in the first four decades of life. Despite multiple reports on how trauma care could be improved in the UK, treatment has been shown to be inconsistent and of poor ...
Hornsby, J., Dignon, N., Quasim, T., Puxty, A.   +3 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Success in the national care of pediatric trauma patients✰,✰✰

Journal of Pediatric Surgery Open
Background: Pediatric trauma patients should be treated at pediatric trauma centers, though not every patient can be transported to one. Our goal was to report outcomes for trauma patients at centers of varying levels of verification by the American ...
Kendall J Burdick, Aixa Perez Coulter, Michael Tirabassi   +2 more
doaj   +1 more source

Impact of direct prehospital transport on mortality in patients with severe trauma based on the injury severity score: a nationwide observational study in the Republic of Korea [PDF]

Osong Public Health and Research Perspectives
Objectives Severe trauma remains a leading cause of death in the Republic of Korea. In response, regional trauma centers were established in 2012. This study evaluated the impact of direct prehospital transport to trauma centers on in-hospital mortality ...
Sun Ju Kim, KeunKyun Kim, Oh Hyun Kim, Chan Yong Park   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source