Results 41 to 50 of about 73,715 (310)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

First rib fractures as an indicator of injury severity in major trauma [PDF]

, 2016
Introduction First rib fractures are traditionally considered indicators of increased morbidity and mortality in major trauma. However, this relationship has not been definitively proven. With an increase in computed tomography in major trauma, and the likely increase in detection of first rib ...
Sammy, I.A., Chatha, H., Lecky, F., Bouamra, O., Fragoso Iniguez, M., Sattout, A., Hickey, M.   +6 more
openaire   +2 more sources

Early Mortality Risk in Acute Trauma Patients: Predictive Value of Injury Severity Score, Trauma Index, and Different Types of Shock Indices

Journal of Clinical Medicine, 2022
Objective: This study aimed to explore the predictive value of the Injury Severity Score (ISS), Trauma Index (TI) and different types of shock indices (SI) on the early mortality risk of acute trauma patients. Methods: Clinical data of acute trauma patients who met the inclusion and exclusion criteria of this study and were treated in the hospital from
Guoyang Dai, Xin Lu, Feng Xu, Deli Xu, Pengfei Li, Xionghui Chen, Fengbao Guo   +6 more
openaire   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Trauma severity predictors

Medicina, 2023
This review aimed to determine which are the indexes for early detection and evaluation of clinical and physiological deterioration of traumatized patients.
André Luís Antoneli Senju, Giovanna Cristina Conti Machado-Kayzuka, Luís Expedito Sabage, Carlos Antonio Negrato, Aguinaldo César Nardi, Cezar Kayzuka Cotta Filho, Alessandra Mazzo   +6 more
doaj  

Trauma Registry: Trauma Quality indicators analysis in hospitalized patients [PDF]

Revista do Colégio Brasileiro de Cirurgiões
Purpose: to consolidate a Trauma Register (TR) trough REDCap data acquisition platform and to validate, in this context, local Quality Indicators (QI) as improvement opportunities in trauma management.
LUCA GIOVANNI ANTONIO PIVETTA, PEDRO DE SOUZA LUCARELLI ANTUNES, GIOVANNA MENNITTI SHIMODA, JOSÉ GUSTAVO PARREIRA, JACQUELINE ARANTES GIANNINNI PERLINGEIRO, JOSE CESAR ASSEF   +5 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Trauma torácico: análise de 124 pacientes submetidos à toracotomia

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Analisar os pacientes submetidos à toracotomia para o tratamento de traumatismo torácico. MÉTODOS: Estudo retrospectivo por meio da análise de prontuários nos dois principais hospitais de referência para trauma em adultos desta cidade, por um ...
Fernando Luiz Westphal, Luiz Carlos de Lima, José Correa Lima Netto, Jeancarllo de Souza da Silva, Vítor Lazarini dos Santos Júnior, Danielle Cristine Westphal   +5 more
doaj   +1 more source

Pattern of Chest Injuries and Role of Intercostal Chest Drain in Patients Presenting with Blunt Trauma: A Research Protocol [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Chest trauma remains a significant contributor to morbidity and mortality worldwide, particularly in rural areas where access to advanced healthcare services is limited.
Pankaj Babubhai Katariya, Swati Deshpande   +1 more
doaj   +1 more source

Computerised tomography indices of raised intracranial pressure and traumatic brain injury severity in a New Zealand sample [PDF]

, 2012
After traumatic brain injury (TBI) complex cellular and biochemical processes occur¹ including changes in blood flow and oxygenation of the brain; cerebral swelling; and raised intracranial pressure (ICP).² This can dramatically worsen the damage³ and ...
Barker-Collo, Suzanne, Feigin, Valery L., Kahan, Michael, Starkey, Nicola J., Theadom, Alice   +4 more
core   +1 more source