Results 31 to 40 of about 148,004 (286)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Severe Traumatic Brain Injury [PDF]

Neurosurgery, 2017
Background: Inadvertent hyperventilation is associated with poor outcomes from traumatic brain injury (TBI). Hypocapnic cerebral vasoconstriction is well described and causes an immediate and profound decrease in cerebral perfusion. The hemodynamic effects of positive-pressure ventilation (PPV) remain incompletely understood but may be equally ...
David L, Penn, John H, Chi, Mark R, Proctor   +2 more
openaire   +2 more sources

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

TRAUMATIC BRAIN INJURY–INDUCED INFLAMMATION AND GASTROINTESTINAL MOTILITY DYSFUNCTION [PDF]

, 2023
Abigail R. Cannon, Lillian Anderson, Kevin E Galicia, Mary Grace Murray, Aadil S. Kamran, Xiaoling Li, Richard P. Gonzalez, Mashkoor A. Choudhry   +7 more
openalex   +1 more source

The Impact of Tilburg Frailty on Poststroke Fatigue in First‐Ever Stroke Patients: A Cross‐Sectional Study With Unified Measurement Tools and Improved Statistics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen, Xiao‐Xue Wang, Shao‐Rui Bao, Sui‐Li Lin, Mei‐Chun Shu, Xi‐Xi Ye, Wen‐Jie Cong   +6 more
wiley   +1 more source

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song, Yi Ju, Hongqiu Gu, Zhikai Zhu, Zixiao Li, Qian Zhang, Xingquan Zhao   +6 more
wiley   +1 more source

Initial prognoctic factors of traumatic brain injury, complicate by acute, traumatic subdural hematoma and epidural hematoma and their association with outcome

Journal of Education, Health and Sport, 2017
Traumatic brain injury (TBI) is not just one disease, but includes a wide spectrum alteration in brain function, or other evidence of brain pathology caused by external force.  The most important effect of traumatic brain injury is the development of the
Bartłomiej Kulesza, Paweł Szmygin, Adam Nogalski   +2 more
doaj   +3 more sources

Aquaporins in Acute Brain Injury: Insights from Clinical and Experimental Studies

Biomedicines
Aquaporins (AQPs) are a family of transmembrane water channel proteins facilitating the transport of water and, in some cases, small solutes such as glycerol, lactate, and urea.
Stelios Kokkoris, Charikleia S. Vrettou, Nikolaos S. Lotsios, Vasileios Issaris, Chrysi Keskinidou, Kostas A. Papavassiliou, Athanasios G. Papavassiliou, Anastasia Kotanidou, Ioanna Dimopoulou, Alice G. Vassiliou   +9 more
doaj   +1 more source

Head Injury- A Maxillofacial Surgeon’s Perspective [PDF]

Journal of Clinical and Diagnostic Research, 2016
Injuries and violence are one of the leading causes of mortality worldwide. A substantial portion of these injuries involve the maxillofacial region. Among the concomitant injuries, injuries to the head and cervical spine are amongst those that demand ...
MURALEE MOHAN CHOONTHAR, ANANTHAN RAGHOTHAMAN, RAJENDRA PRASAD, S PRADEEP, KALPA PANDYA   +4 more
doaj   +1 more source