Results 101 to 110 of about 570,549 (333)

Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2018
Importance After severe traumatic brain injury, induction of prophylactic hypothermia has been suggested to be neuroprotective and improve long-term neurologic outcomes.
D. J. Cooper, A. Nichol, M. Bailey, S. Bernard, P. Cameron, S. Pili-Floury, A. Forbes, D. Gantner, Alisa M. Higgins, O. Huet, J. Kasza, L. Murray, L. Newby, Jeffrey J. Presneill, S. Rashford, Jeffrey V. Rosenfeld, M. Stephenson, S. Vallance, D. Varma, Steven A R Webb, T. Trapani, C. McArthur   +21 more
semanticscholar   +1 more source

Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments

Advanced Healthcare Materials, EarlyView.
Granular hydrogels are emerging microporous platforms for cell culture and delivery, showing great potential for replicating the complex, heterogeneous environments found in natural tissues. This review outlines the design principles of granular hydrogels, highlighting critical factors that determine the final physicochemical properties of the entire ...
Shuhan Feng, Kaiyang Chen, Shiqi Wang
wiley   +1 more source

The Effect of Hypoxia on Traumatic Head Injury in Rats: Alterations in Neurologic Function, Brain Edema, and Cerebral Blood Flow [PDF]

, 1987
Naoki Ishige, Lawrence H. Pitts, I. Berry, Sara Carlson, Merry Nishimura, Michael E. Moseley, Philip R. Weinstein   +6 more
openalex   +1 more source

Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury.

Brain : a journal of neurology, 2019
Traumatic microbleeds are small foci of hypointensity seen on T2*-weighted MRI in patients following head trauma that have previously been considered a marker of axonal injury.
Allison D Griffin, L. Turtzo, Gunjan Y. Parikh, A. Tolpygo, Zachary Lodato, Anita D Moses, G. Nair, Daniel P Perl, Nancy A Edwards, B. Dardzinski, Regina C Armstrong, A. Ray‐Chaudhury, P. P. Mitra, L. L. Latour   +13 more
semanticscholar   +1 more source

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source

Mesenchymal Stromal Cell Secretome and Its Key Bioactive Metabolites Induce Long‐Term Neuroprotection After Traumatic Brain Injury in Mice

Advanced Science
The severe and long‐term consequences of traumatic brain injury (TBI) highlight the urgent need for effective neuroprotective therapies. Mesenchymal stromal cells (MSCs) show promise in TBI treatment through their secretome (conditioned media, CM). A low‐
Francesca Pischiutta, Francesca Tribuzio, Marta Magatti, Giulia De Simone, Federico Moro, Giovanni Nattino, Fabiola Signorini, Luther Loose, Enrico Caruso, Costanza Bertani, Edoardo Mazzone, Rosaria Pascente, Edoardo Micotti, Antonietta Rosa Silini, Fabrizio Ortolano, Maria Chiara Trolese, Marco Bolis, Luca Guarrera, Martina Bruna Violatto, Paolo Bigini, Cristina Banfi, Roberta Pastorelli, Ornella Parolini, Laura Brunelli, Elisa R Zanier   +24 more
doaj   +1 more source

Unhealthy family functioning is strongly associated with warfighter brain health following traumatic brain injury in United States service members and veterans

Frontiers in Neurology
ObjectiveTo examine the relationship between family functioning and health-related quality of life (HRQOL) outcomes following traumatic brain injury (TBI) in service members and veterans (SMVs).ParticipantsParticipants were 359 United States SMVs ...
Tracey A. Brickell, Tracey A. Brickell, Tracey A. Brickell, Tracey A. Brickell, Louis M. French, Louis M. French, Louis M. French, Brian J. Ivins, Brian J. Ivins, Sara M. Lippa, Sara M. Lippa, Megan M. Wright, Megan M. Wright, Megan M. Wright, Samantha M. Baschenis, Samantha M. Baschenis, Samantha M. Baschenis, Jamie K. Sullivan, Jamie K. Sullivan, Jamie K. Sullivan, Lars D. Hungerford, Lars D. Hungerford, Rael T. Lange, Rael T. Lange, Rael T. Lange, Rael T. Lange   +25 more
doaj   +1 more source

Marked Protection by Moderate Hypothermia after Experimental Traumatic Brain Injury [PDF]

, 1991
Guy L. Clifton, Ji Y. Jiang, Bruce G. Lyeth, Larry W. Jenkins, Robert J. Hamm, Ronald L. Hayes   +5 more
openalex   +1 more source

Coordinated Development of Immune Cell Populations in Vascularized Skin Organoids from Human Induced Pluripotent Stem Cells

Advanced Healthcare Materials, EarlyView.
Vascularized skin organoids are developed from human induced pluripotent stem cells and contain macrophages, Langerhans cells, and neutrophils. Vascularized skin organoids offer a transformative platform to model skin biology and enable mechanistic investigations of inflammatory and hematologic skin disorders.
Mitchell Mostina, Jane Sun, Seen Ling Sim, Imaan A. Ahmed, Fernando Souza‐Fonesca‐Guimaraes, Ernst J. Wolvetang, Jason Brown, Snehlata Kumari, Kiarash Khosrotehrani, Abbas Shafiee   +9 more
wiley   +1 more source

A Comprehensive Review of Clinical Studies on Bacterial Cellulose: From the Earliest Uses to Contemporary Innovations

Advanced Healthcare Materials, EarlyView.
Bacterial cellulose has undergone a transformative journey from early applications to its role in advanced regenerative medicine. The review has a pedagogical ambition, offering clear pathways for future research and clinical adoption. Harmonizing regulatory standards and conducting larger, well‐designed clinical trials with standardized endpoints will
Thomas Meslier, Justin Christopher D'Antin, Gemma Julio, Anna Roig   +3 more
wiley   +1 more source