Results 51 to 60 of about 570,549 (333)

LncBIRC3-OT promotes the malignant progression of glioma by interacting with RELA to upregulate stanniocalcin-1 expression

Heliyon, 2023
Glioma is the most common malignant intracranial tumor, accounting for 80 % of all malignant brain tumors. Growing evidence suggests that lncRNAs are involved in the growth, angiogenesis, metastasis, and therapeutic resistance in a variety of tumors ...
Renjie Wang, Qi Li, Xiaolei Chu, Nan Li, Haiqian Liang, Feng He   +5 more
doaj   +1 more source

Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines.

Pediatric Critical Care Medicine, 2019
Severe Traumatic Brain Injury in Infants, Children, and Adolescents in 2019: Some Overdue Progress, Many Remaining Questions, and Exciting Ongoing Work in the Field of Traumatic Brain Injury ResearchIn this Supplement to Pediatric Critical Care Medicine,
P. Kochanek, Robert C. Tasker, N. Carney, Annette M. Totten, P. Adelson, N. Selden, C. Davis-O’Reilly, Erica L. Hart, Michael J. Bell, S. Bratton, Gerald A. Grant, N. Kissoon, Karin E. Reuter-Rice, M. Vavilala, Mark S. Wainwright   +14 more
semanticscholar   +1 more source

Neuroenergetics of traumatic brain injury [PDF]

Concussion, 2016
A subset of traumatic brain injury (TBI) patients exhibit cognitive deficits later in life which may be due to the underlying pathology associated with Alzheimer's disease (AD) or chronic traumatic encephalopathy. The similarities between chronic traumatic encephalopathy and AD merit investigation of potentially similar mechanisms underlying the two ...
Zachary M. Weil, Kate Karelina
openaire   +5 more sources

Genetic Modifiers of Parkinson's Disease: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik, Michael V. Holmes, Pierre Fontanillas, Giulietta M. Riboldi, Ruth B. Schneider, Jingchunzi Shi, Anna Guan, Susana Tat, Steven Micheletti, Keaton Stagaman, Josh Gottesman, David A. Hinds, Joyce Y. Tung, 23andMe Research Team, Stella Aslibekyan, Lucy Norcliffe‐Kaufmann   +15 more
wiley   +1 more source

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis

Nature Communications, 2019
Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause severe deficits in meningeal lymphatic drainage that begin within hours and ...
Ashley C. Bolte, A. Dutta, Mariah E. Hurt, Igor Smirnov, M. Kovacs, Celia A. McKee, Hannah E Ennerfelt, Daniel A. Shapiro, Bao H. Nguyen, Elizabeth L. Frost, Catherine R. Lammert, J. Kipnis, J. Lukens   +12 more
semanticscholar   +1 more source

Experimental traumatic brain injury [PDF]

Experimental & Translational Stroke Medicine, 2010
Traumatic brain injury, a leading cause of death and disability, is a result of an outside force causing mechanical disruption of brain tissue and delayed pathogenic events which collectively exacerbate the injury. These pathogenic injury processes are poorly understood and accordingly no effective neuroprotective treatment is available so far ...
Albert-Weissenberger, Christiane, Sirén, Anna-Leena   +1 more
openaire   +4 more sources

Exploring Nasal Structural‐Microbial Interactions in Multiple Sclerosis‐Associated Olfactory Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition,
Zidan Gao, Zhuoma Danzhen, Yao Li, Junyu Zhu, Lan Chu, Zhang Yang   +5 more
wiley   +1 more source

Recent advances in traumatic brain injury

Journal of Neurology, 2019
Traumatic brain injury (TBI) is the most common cause of death and disability in those aged under 40 years in the UK. Higher rates of morbidity and mortality are seen in low-income and middle-income countries making it a global health challenge.
Abdelhakim Khellaf, D. Khan, A. Helmy
semanticscholar   +1 more source

Characteristics of Cerebral Palsy in the Midwestern US

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebral palsy (CP) is the most common lifelong motor disability worldwide. Yet, data is limited on how CP manifests in the US. Our objective was to characterize and determine factors affecting functional outcomes in a large population of young people with CP in the Midwestern US.
Susie Kim, Kelsey Steffen, Lauren Gottschalk‐Henneberry, Jennifer Miros, Amy Robichaux‐Viehoever, Karen Taca, Bhooma R. Aravamuthan   +6 more
wiley   +1 more source

Validation of the Early Functional Abilities scale: An assessment of four dimensions in early recovery after traumatic brain injury

Journal of Rehabilitation Medicine, 2018
Objective: The Early Functional Abilities scale assesses the restoration of brain function after brain injury, based on 4 dimensions. The primary objective of this study was to evaluate the validity, objectivity, reliability and measurement precision of ...
Ingrid Poulsen, Svend Kreiner, Aase W. Engberg   +2 more
doaj   +1 more source