Results 81 to 90 of about 1,075,156 (295)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
An Anatomy of the French Labour Market [PDF]
, 2013 [Excerpt] Over the last decades, many European countries have experienced high and persistent unemployment rates. The bulk of labour market research has tackled this issue by emphasizing the effect of employment protection legislation, hereafter EPL, on ...
Le Barbanchon, Thomas, Malherbet, Franck
core +1 more source
Lien Social et PolitiquesCet article découle d’une recherche qualitative menée auprès de quelques travailleur.euses, salarié.es ou non, de neuf initiatives économiques autogérées fondées en Amérique du Nord entre 1999 et 2019.
Marie-Pierre Boucher
doaj +1 more source
L’appropriation de l’espace aux marges du dispositif de production
Carnets de Géographes, 2023 À partir d’un travail d’entretien ethnographique et d’entretiens semi-directifs réalisés sur des grands chantiers du bâtiment en région Sud et auprès de différents travailleurs, cet article propose une géographie des chantiers à l’échelle micro-locale ...
Marguerite Valcin
doaj
Journal of French and Francophone Philosophy, 2019 Cet article propose une réflexion sur la protection des capacités au travail à partir de Martha Nussbaum. Sa visée est de penser les conditions institutionnelles de l’accès aux capacités, dans le cadre du travail, en mettant en évidence les points de ...
Cécile Ezvan
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Études Ricoeuriennes / Ricoeur Studies, 2019 Paul Ricœur’s dialogue has been constant with the human and social sciences, but with little attention given to economics. This Ricœurian silence on the economy is relative.
Jean-Philippe Pierron
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Trade liberalization and demand labor elasticities : evidence from Tunisia [PDF]
Ce papier étudie les effets de la libéralisation des échanges sur les élasticités de la demande du travail. Une équation de demande d'emploi est estimée en se fondant sur des données (1971-1996) portant sur six industries manufacturières tunisiennes. Les
Ilham Haouas, Mahmoud Yagoubi
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source