Results 51 to 60 of about 566,371 (309)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Metro Train Operation Plan Analysis Based on Station Travel Time Reliability

open access: yesJournal of Advanced Transportation, 2021
The train operation plan plays an essential role in metro systems and directly affects transportation organization efficiency and passenger service level.
Ruihua Xu, Fangsheng Wang, Feng Zhou
doaj   +1 more source

Estimation of the Network Reliability for a Stochastic Cold Chain Network with Multi-State Travel Time

open access: yesApplied Sciences, 2023
A stochastic cold chain (SCC) is a common supply chain in real life that emphasizes the need for commodities to arrive fresh within time constraints. In previous research on supply chains, the time factor was regarded as a fixed number.
Thi-Phuong Nguyen   +2 more
doaj   +1 more source

A new measure of travel time reliability for in-vehicle navigation systems [PDF]

open access: yes, 2008
This article introduces a new measure of travel time reliability for implementation in the dynamic routing algorithm of an intelligent car navigation system. The measure is based on the log-normal distribution of travel time on a link and consists of two
Bell, M. G. H.   +2 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

CONSIDERING TRAVEL TIME RELIABILITY AND SAFETY FOR EVALUATION OF CONGESTION RELIEF SCHEMES ON EXPRESSWAY SEGMENTS

open access: yesIATSS Research, 2009
Evaluation of the efficiency of congestion relief schemes on expressways has generally been based on average travel time analysis. However, road authorities are much more interested in knowing the possible impacts of improvement schemes on safety and ...
Babak MEHRAN
doaj   +1 more source

Last-Mile Shuttle Planning for Improving Bus Commuters’ Travel Time Reliability: A Case Study of Beijing

open access: yesJournal of Advanced Transportation, 2022
This study proposes a multiobjective mixed integer nonlinear programming model for a last-mile shuttle service to improve bus commuters’ travel time reliability.
Weibin Kou   +3 more
doaj   +1 more source

Modelling Travel Time Reliability with the Burr Distribution

open access: yesProcedia - Social and Behavioral Sciences, 2012
AbstractThis paper suggests the Burr distribution as a useful statistical model to represent travel time reliability through studies of the day-to-day variability in travel times on journeys in urban areas. This distribution has a flexible shape and the ability to describe the very long upper tails (and hence significant skewness) seen in observed ...
Taylor, Michael.A.P., Susilawati,
openaire   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

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