Results 71 to 80 of about 1,181,987 (277)

TARGETING TRYPTOPHAN-KYNURENINE METABOLISM TO EXTEND LIFESPAN AND TREAT AGE-ASSOCIATED DISEASE [PDF]

Innovation in Aging, 2019
Abstract The kynurenine pathway, the major route for tryptophan catabolism, becomes dysregulated with age and in many age-associated pathologies in humans. Interventions targeting kynurenine metabolism are being pursued for neurodegeneration, cardiovascular disease, and chronic kidney disease.
Sutphin, George L, Sutphin, George L
openaire   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Complex reflection groups, logarithmic connections and bi-flat F-manifolds

, 2016
We show that bi-flat $F$-manifolds can be interpreted as natural geometrical structures encoding the almost duality for Frobenius manifolds without metric.
Arsie, Alessandro, Lorenzoni, Paolo
core   +1 more source

[Intracranially extended nasopharyngeal angiofibroma treated surgically and by radiotherapy].

Otolaryngologia polska = The Polish otolaryngology, 2004
A case of nasopharyngeal angiofibroma with intracranial extension is presented. The parasellar extension was demonstrated on CT and MRI scans after four operations performed in two centres. The boy was radiated (42 Gy/t). Two and a half years follow up using MRI showed gradual regression of the tumour down to minimal enhancement in the parasellar ...
Anna, Szymańska, Henryk, Siwiec, Marcin, Szymański, Radosław, Pietura, Maria, Mazurkiewicz   +4 more
openaire   +1 more source

Feasibility and Safety of High‐Dose Proton Re‐Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single‐Institution Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song, Jonathan Baron, Carlos Chavez Perez, Sidharth Ramesh, Jane Minturn, Kavita A. Desai, Amish C. Shah, Jean M. Belasco, Kristina A. Cole, Michael J. Fisher, Phillip B. Storm, Peter M. Madsen, Goldie Kurtz, Robert A. Lustig, Christine Hill‐Kayser, Michael J. LaRiviere   +15 more
wiley   +1 more source

Review of Guideline Recommendations for Optimal Anti-VEGF Therapy in Age-Related Macular Degeneration

Life
Neovascular age-related macular degeneration is a progressive, blinding macular disease that has become a burden both in healthcare systems and the global economy. The vascular endothelial growth factor (VEGF) is the main agent involved in the pathogenic
Andreea Dana Moraru, Ciprian Danielescu, Raluca Eugenia Iorga, Radu Lucian Moraru, Mihail Zemba, Daniel Constantin Branisteanu   +5 more
doaj   +1 more source

Pediatric pulmonary mucormycosis in a diabetic patient treated with extended pleurectomy and Clagett procedure [PDF]

Journal of Pediatric Surgery Case Reports, 2019
Mucor is a ubiquitous fungus that is non-pathogenic in healthy people. In immunocompromised hosts, non-functional or absent neutrophils and macrophages result in fungal invasion and infection [1]. Invasive mucor (mucormycosis) most commonly involves the sinuses, brain, or lungs.
Gologorsky, Rebecca C, Ely, Sora, Rothenberg, Kara A, Glaser, Carol, Velotta, Jeffrey B   +4 more
openaire   +3 more sources

Defining Roles in Pediatric Palliative Care: Perspectives From Oncology and Palliative Care Teams

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Early integration of pediatric palliative care (PPC) is associated with improved symptom management, quality of life, and healthcare utilization for children with cancer. Despite this, variation persists in how PPC is understood, operationalized, and integrated within pediatric oncology programs. In particular, ambiguity surrounding
Leeat Granek, Lori Wiener, Stephanie Veldhuijzen van Zanten, Donna Johnston, Fyeza Hasan, Adam Rapoport, Nathasha Datoo, Kimberley Widger, Sumit Gupta, Karen Fergus, Anthony K. C. Chan, Alisha Kassam, Emily McCullogh, Dave Lysecki   +13 more
wiley   +1 more source

Pharmacoeconomic analysis of anti-VEGF therapy for age-related macular degeneration

Качественная клиническая практика, 2018
Diabetes mellitus (DM) is a widespread, severe disease that has outpaced many infectious and non-infectious diseases in terms of both incidence increases and economic burden in most developed countries.
A. E. Cheberda, D. Yu. Belousov, M. M. Shishkin   +2 more
doaj   +1 more source

Optimization of Composition and Heat Treating of Die Steels for Extended Lifetime [PDF]

, 2002
An ''average'' die casting die costs fifty thousand dollars. A die used in making die cast aluminum engine blocks can cost well over one million dollars. These costs provide a strong incentive for extension of die life. While vacuum quenched Premium Grade H13 dies have become the most widely used in the United States, tool makers and die casters are ...
Schwam, David, Wallace, John F., Zhou, Quanyou   +2 more
openaire   +2 more sources