Results 91 to 100 of about 210,707 (288)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Real-World Outcomes of Switching to Faricimab in Treatment-Experienced and Resistant Neovascular Age-Related Macular Degeneration: A Single-Centre Retrospective Study

Clinical Ophthalmology
Christopher Stewart,1 Jaskaran Singh Bhangu,2 Parinita Keshav Swarnkar,2 Mohammed Rifat,2 Sarah Khalid,2 Ahmed Al-Janabi,2 Mahmoud H Awad,2 Gwyn Samuel Williams2 1Faculty of Medicine, Health, and Life Science, Swansea University, Swansea, Wales, UK ...
Stewart C, Bhangu JS, Swarnkar PK, Rifat M, Khalid S, Al-Janabi A, Awad MH, Williams GS   +7 more
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Confluent and reticulated papillomatosis treated with extended-release minocycline

Indian Dermatology Online Journal, 2023
Fathima Shafi, M Manjunath Shenoy, Deepa M Thomas, Malcolm Pinto   +3 more
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Treat-And-extend bevacizumab for neovascular age-related macular degeneration: The importance of baseline characteristics

, 2014
PURPOSE:: To evaluate the factors affecting visual and anatomical outcomes and the number of intravitreal bevacizumab injections required in the treatment of neovascular age-related macular degeneration using a treat-And-extend regimen.
Aragon, AV, Rush, RB, Simunovic, MP, Vandiver, L, Ysasaga, JE   +4 more
core   +1 more source

Effect of Ranibizumab and Aflibercept on Best-Corrected Visual Acuity in Treat-and-Extend for Neovascular Age-Related Macular Degeneration: A Randomized Clinical Trial. [PDF]

, 2019
Importance To our knowledge, this is the first randomized clinical trial to compare visual outcomes and injection loads between ranibizumab and aflibercept using an identical treat-and-extend (TE) regimen for neovascular age-related macular ...
Hunyor, Alex P, Gillies, Mark C, McAllister, Ian L, Pecheur, Francois L, Guymer, Robyn H, Arnold, Jennifer J, Ng, Paul, Wolf, Sebastian   +7 more
core   +1 more source

Neovascular Age-Related Macular Degeneration Treated with Aflibercept: Five-Year Follow-Up and Correlation with Optical Coherence Tomography Biomarkers in a Real-World Setting

Ophthalmology and Therapy
Introduction To evaluate long-term outcomes of neovascular age-related macular degeneration(nAMD) treatment with aflibercept in a treat-and-extend (T&E) regimen and explore correlations between optical coherence tomography (OCT) biomarkers and clinical ...
Massimiliano Borselli, Mutasem Elfalah, Teresa Angela Trunfio, Arianna Scala, Domenico Chisari, Alessandra Mancini, Andrea Lucisano, Giovanna Carnovale-Scalzo, Vincenzo Mollace, Giovanni Improta, Sandrine Zweifel, Vincenzo Scorcia, Mario Damiano Toro, Adriano Carnevali   +13 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Imperforate nasopharynx in a cat successfully treated with an extended palatoplasty

Journal of Feline Medicine and Surgery Open Reports
Case summary A female intact domestic shorthair kitten was evaluated at 8 months of age for bilateral mucopurulent nasal discharge, stertor, open-mouth breathing and difficulty eating. Imperforate nasopharynx (INP) was diagnosed on oronasal examination under anesthesia. An extended palatoplasty was performed and
openaire   +3 more sources