Results 111 to 120 of about 210,707 (288)

Risk-based Algorithm-guided Treatment Protocol for the Management of Neovascular Age-related Macular Degeneration

Türk Oftalmoloji Dergisi, 2019
Objectives:To assess outcomes of a risk-based algorithm-guided treatment protocol for neovascular age-related macular degeneration.Materials and Methods:Two hundred and ten eyes of 184 patients managed with anti-vascular endothelial growth factor (anti ...
Murat Karaçorlu, Mümin Hocaoğlu, Serra Arf, M. Giray Ersöz, Işıl Sayman Muslubaş   +4 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Comparative study on the efficacy of different aflibercept regimens in the treatment of macular edema secondary to branch retinal vein occlusion

Frontiers in Medicine
ObjectivesTo compare the efficacy of intravitreal injection of aflibercept between the treat-and-extend (TAE) and pro re nata (PRN, as needed) regimens in the treatment of macular edema secondary to branch retinal vein occlusion, to determine the best ...
Xing Du, Yuanyuan Guo, Min Du, Wen Wang, Mingkun Liu, Shanshan Li, Yanjuan Sheng   +6 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Changes in metamorphopsia after the treat-and-extend regimen of anti-VEGF therapy for macular edema associated with branch retinal vein occlusion.

, 2020
This study aims to investigate the changes in metamorphopsia after administering the treat-and-extend regimen of anti-vascular endothelial growth factor therapy for branch retinal vein occlusion-associated macular edema.
Shigeo Yoshida, Koh-Hei Sonoda, Keijiro Ishikawa, Kenichiro Mori, Masatoshi Haruta, Takahito Nakama, Masato Akiyama, Yoshiyuki Kobayashi, Shintaro Nakao, Iori Wada, Yuki Kubo   +10 more
core   +1 more source

Relationships between Patient-Reported Outcome Measures and Clinical Measures in Naïve Neovascular Age-Related Macular Degeneration Patients Treated with Intravitreal Ranibizumab

Pharmaceuticals
Our objective was to evaluate changes in patient-reported outcome measures using the NEI-VFQ 25 questionnaire during a treat and extend regimen in naive neovascular Age-Related Macular Degeneration patients, and its correlation with anatomical and ...
Pablo Almuiña-Varela, Laura García-Quintanilla, María José Rodríguez-Cid, María Gil-Martínez, Maximino J. Abraldes, Francisco Gómez-Ulla, Ana Estany-Gestal, Jorge Miguel Alcántara-Espinosa, Maribel Fernández-Rodríguez, Anxo Fernández-Ferreiro   +9 more
doaj   +1 more source

Extending the Reach of Interventions to Treat Mental Disorders

Psychiatry International
The majority of people with mental disorders in low-, middle-, and high-income countries do not receive any intervention for their symptoms, despite enormous advances in developing evidence-based psychosocial treatments and medications. The perspective and viewpoint article discusses and illustrates digital and technology-based interventions and ...
openaire   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

One-Year Outcomes of a Treat-and-Extend Regimen of Aflibercept for Exudative Age-Related Macular Degeneration

, 2017
<b><i>Purpose:</i></b> The aim of this study was to investigate the 1-year outcomes of treat-and-extend aflibercept for exudative age-related macular degeneration (AMD) in Japan.
Hiroaki Kobayashi, Akiko Yamamoto, Annabelle A. Okada, Makiko Nakayama, Yumiko Yoshida   +4 more
core   +1 more source

Challenging the Treatment Threshold: Early Faricimab Prevents Vision Loss in nAMD &ndash; A Real-World Welsh Experience

Clinical Ophthalmology
Parinita Keshav Swarnkar,1 Jaskaran Singh Bhangu,1 Christopher Stewart,2 Mohammed Rifat,1 Sarah Khalid,1 Harry Winkworth,2 Savannah Lydia Franklin-Goddard,2 Mahmoud Husseiny Awad,1 Gwyn Samuel Williams1 1Ophthalmology Department, Singleton Hospital ...
Swarnkar PK, Singh Bhangu J, Stewart C, Rifat M, Khalid S, Winkworth H, Franklin-Goddard SL, Awad MH, Williams GS   +8 more
doaj