Results 191 to 200 of about 6,753,495 (314)

Genetics and Neurobiology of Treatment-Resistant Depression-A Review. [PDF]

Int J Mol Sci
Płaza O, Gałecki P, Bliźniewska-Kowalska K, Gałecka M, Brońska A, Płaza J, Szurek A, Szulc A.   +7 more
europepmc   +1 more source

Treatment resistant but not irremediable

Bipolar Disorders
Malhi, GS, Bell, E, Le, U, Boyce, P, Berk, M   +4 more
openaire   +3 more sources

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Japanese psychiatrists' perceptions of surgical treatment for treatment-resistant obsessive compulsive disorder: A nationwide survey. [PDF]

PCN Rep
Morishita T, Kito S, Yamashiro K, Konno D, Arima H, Abe H, Iwasaki M.   +6 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Ketamine or Esketamine in Special Populations of Patients With Treatment-Resistant Depression. [PDF]

Med Sci Monit
Grabarczyk Ł, Wolfermann SR, Oniszczuk H, Radkowski P.   +3 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Efficacy Evaluation of Luliconazole-Loaded Nanostructured Lipid Carriers in Treatment-Resistant Dermatophytosis: A Randomized Clinical Trial. [PDF]

Mycoses
Barogh RE, Jeddi SA, Rokni GR, Fam HMT, Raeisabadi A, Yahyazadeh Z, Rahimnia SM, Ebrahimnejad P, Nazar E, Gholizadeh N, Haghani I, Nosratabadi M, Kazeminejad A, Javidnia J, Hedayati MT, Meis JF, Al-Harrasi A, Abastabar M, Al-Hatmi AMS.   +18 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

GWAS and Replication Analysis of Apparent Treatment-Resistant Hypertension. [PDF]

Hypertension
Ebinger JE, Kauko A, Vaura F, Hage P, Sundström J, FinnGen, Joung SY, Cheng S, Niiranen TJ.   +8 more
europepmc   +1 more source