Results 11 to 20 of about 259,075 (330)

Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms [PDF]

Scientific Reports, 2017
Psilocybin with psychological support is showing promise as a treatment model in psychiatry but its therapeutic mechanisms are poorly understood.
Bolstridge, Mark, Carhart-Harris, Robin L, Curran, H Valerie, Demetriou, Lysia, Kaelen, Mendel, Leech, Robert, McGonigle, John, Murphy, Kevin, Nutt, David J, Pannekoek, J Nienke, Roseman, Leor, Tanner, Mark, Wall, Matthew B   +12 more
core   +5 more sources

Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions

World Psychiatry, 2023
Treatment‐resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD with demonstrated predictive utility in terms of clinical decision‐making and health outcomes does not currently
R. McIntyre, M. Alsuwaidan, B. Baune, Michael Berk, K. Demyttenaere, Joseph F. Goldberg, P. Gorwood, R. Ho, Siegfried Kasper, Sidney H. Kennedy, Josefina T Ly-Uson, R. Mansur, R. McAllister-Williams, J. Murrough, C. B. Nemeroff, A. Nierenberg, J. Rosenblat, Gerard Sanacora, Alan F. Schatzberg, Richard C. Shelton, Stephen M. Stahl, Madhukar H. Trivedi, Eduard Vieta, M. Vinberg, Nolan Williams, Allan H. Young, M. Maj   +26 more
semanticscholar   +1 more source

Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.

American Journal of Psychiatry, 2021
Replicated international studies have underscored the human and societal costs associated with major depressive disorder. Despite the proven efficacy of monoamine-based antidepressants in major depression, the majority of treated individuals fail to ...
R. McIntyre, J. Rosenblat, C. Nemeroff, G. Sanacora, J. Murrough, M. Berk, E. Brietzke, S. Dodd, P. Gorwood, R. Ho, D. Iosifescu, C. L. López Jaramillo, S. Kasper, Kevin Kratiuk, J. G. Lee, Yena Lee, L. Lui, R. Mansur, G. Papakostas, M. Subramaniapillai, M. Thase, E. Vieta, A. Young, C. Zarate, S. Stahl   +24 more
semanticscholar   +1 more source

Psilocybin for treatment resistant depression in patients taking a concomitant SSRI medication

Neuropsychopharmacology, 2023
Psilocybin is being investigated as a treatment in adults with treatment-resistant depression (TRD). Withdrawal from serotonergic antidepressant drugs is a common prerequisite for taking part in trials of psilocybin due to the possibility of ongoing ...
G. Goodwin, M. Croal, D. Feifel, John R. Kelly, L. Marwood, S. Mistry, V. O’Keane, S. K. Peck, H. Simmons, C. Sisa, S. Stansfield, J. Tsai, S. Williams, E. Malievskaia   +13 more
semanticscholar   +1 more source

Long-term safety and maintenance of response with esketamine nasal spray in participants with treatment-resistant depression: interim results of the SUSTAIN-3 study

Neuropsychopharmacology, 2023
Patients with treatment-resistant depression (TRD) have higher rates of relapse and pronounced decreases in daily functioning and health-related quality of life compared to patients with major depressive disorder who are not treatment-resistant ...
N. Zaki, Li (Nancy) Chen, R. Lane, Teodora Doherty, W. Drevets, Randall L. Morrison, G. Sanacora, S. Wilkinson, V. Popova, D. Fu   +9 more
semanticscholar   +1 more source

The Prevalence and National Burden of Treatment-Resistant Depression and Major Depressive Disorder in the United States.

Journal of Clinical Psychiatry, 2021
OBJECTIVE Estimates of prevalence and burden of treatment-resistant depression (TRD) vary widely in the literature. This study evaluated the prevalence and burden of TRD and the share of TRD in the burden of medication-treated major depressive disorder ...
M. Zhdanava, D. Pilon, I. Ghelerter, W. Chow, K. Joshi, P. Lefebvre, J. Sheehan   +6 more
semanticscholar   +1 more source

Is treatment resistant depression a different subtype of depression?

European Psychiatry, 2021
Major depression is a serious, disabling, often chronic or recurrent mental disorder affecting over 350 million people worldwide. Treatment of major depression is now conceptualized as proceeding through three phases: the acute phase, the continuation ...
A. Fiorillo
doaj   +1 more source

Treatment Resistant Depression [PDF]

American family physician, 2009
Up to two thirds of patients with major unipolar depression will not respond to the first medication prescribed. Depression may be considered resistant to treatment when at least two trials with antidepressants from different pharmacologic classes (adequate in dose, duration, and compliance) fail to produce a significant clinical improvement.
Philip G. Janicak, Sheila M. Dowd
  +7 more sources

Use of pharmacotherapies for treatment resistant depression in finland: A nationwide cohort study

European Psychiatry, 2021
Introduction There is a lack of knowledge on utilized pharmacotherapies for treatment resistant depression (TRD). Objectives To investigate the courses of treatment of TRD.
H. Taipale, M. Lähteenvuo, A. Tanskanen, S. Rannanpää, J. Tiihonen   +4 more
doaj   +1 more source

Association of Treatment-Resistant Depression With Patient Outcomes and Health Care Resource Utilization in a Population-Wide Study

JAMA psychiatry, 2022
This cohort study examines data for episodes of unipolar major depressive disorder that met criteria for treatment-resistant depression to assess its impact on individuals and society and consider potential prognostic factors.
J. Lundberg, T. Cars, Sven-Åke Lööv, J. Söderling, J. Sundström, J. Tiihonen, A. Leval, A. Gannedahl, C. Björkholm, M. Själin, C. Hellner   +10 more
semanticscholar   +1 more source