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Treatment-Resistant Depression
Psychotherapy and Psychosomatics, 1998Our ability to treat depression has improved with the availability of receptor-specific and chemically diverse groups of antidepressants. Even now, most of the short-term studies indicate that about 20% of depressed patients remain resistant to treatment. Therefore, it is important to properly assess the treatment-resistant depressed (TRD) patients and
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Strategies for treatment-resistant depression
Clinical Cornerstone, 1999Clinical depression is a common disorder with serious implications that is often misdiagnosed or underestimated. More than 50% of suicides are associated with a major depressive disorder, and depression can adversely impact a variety of other medical conditions.
P G, Janicak, B, Martis
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Perspectives for therapy of treatment‐resistant depression
British Journal of Pharmacology, 2021A high proportion of depressed patients fail to respond to antidepressant drug treatment. Treatment‐resistant depression (TRD) is a major challenge for the psychopharmacology of mood disorders. Only in the past decade have novel treatments, including deep brain stimulation (DBS) and ketamine, been discovered that provide rapid and sometimes prolonged ...
Mariusz Papp +4 more
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Esketamine for Treatment-Resistant Depression
JAMA PsychiatryTo the Editor Janik et al reported a positive trial of esketamine monotherapy for treatment-resistant depression. However, the lead-in design and functional unblinding could have biased treatment estimates. The 4-week double-blind phase was preceded by a lead-in phase of up to 7 weeks, during which time antidepressant medication was discontinued ...
Cristea I. A., Plöderl M., Naudet F.
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Treatment resistant depression in elderly
2023Treatment refractory depression (TRD) in the elderly is a common psychiatric disorder with high comorbidity and mortality. Older adults with TRD often have complicated comorbidities and several predisposing risk factors, which may lead to neuropsychiatric dysfunction and poor response to treatment.
Sheng-Chiang, Wang +4 more
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Targeting Treatment-Resistant Depression
Journal of Pharmacy Practice, 2011Only 50% of depressed patients achieve remission of symptoms after 2 trials of antidepressants. Therefore one half of patients are considered treatment resistant. Studies have shown that with each failed antidepressant, chances of remission continue to decline.
Monica, Mathys, Brian G, Mitchell
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Treatment-resistant depression.
The Journal of clinical psychiatry, 2006info:eu-repo/semantics ...
Souery, Daniel +2 more
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Defining treatment‐resistant depression
Depression and Anxiety, 2019Varying conceptualizations of treatment-resistant depression (TRD) have made translating research findings or systematic reviews into clinical practice guidelines challenging and inconsistent.We conducted a review for the Centers for Medicare & Medicaid Services and the Agency for Healthcare Research and Quality to clarify how experts and investigators
Bradley N. Gaynes +12 more
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Esketamine for treatment-resistant depression
Drug and Therapeutics Bulletin, 2020Generic name: Esketamine hydrochloride Brand name: Spravato Formulation: 28mg in 0.2ml nasal spray solution Market Authorisation holder: Janssen-Cilag International NV Indication: Treatment resistant
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Migraine and treatment-resistant depression
2023Migraine and major depressive disorders (MDD) or treatment resistant depression (TRD) represent a significant global burden and are often comorbid, further complicating diagnosis and treatment. Epidemiological studies have demonstrated a bidirectional relationship between migraine and MDD/TRD, with patients suffering from one disorder exhibiting a ...
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