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Overview of treatment-resistant depression

2023
Patients with major depressive disorder (MDD) often exhibit an inadequate treatment response or failure to achieve remission following treatment with antidepressant drugs. Treatment-resistant depression (TRD) is proposed to identify this clinical scenario.
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Clomipramine augmentation in treatment-resistant depression

Depression and Anxiety, 1997
In depression that is resistant to tricyclic antidepressant (TCA) therapy, the substitution of a selective serotonin re-uptake inhibitor (SSRI), clomipramine, or a monoamine oxidase (MAO) inhibitor has been recommended. However, adding an additional antidepressant medication from a different drug class may produce even more rapid efficacy.
J D, Amsterdam   +2 more
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TREATMENT-RESISTANT BIPOLAR DEPRESSION

Psychiatric Clinics of North America, 1996
Patients with treatment-resistant bipolar depression require careful management, which takes into account the life-threatening potential of their depression and the risk of iatrogenic mania. Because there are few data specific to treatment of bipolar depression, much of the approach to bipolar depression is derived from experience with unipolar ...
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Treatment-resistant depression

The Nurse Practitioner
ABSTRACT In 2023, the percentage of people in the US who experienced depression in their lifetime was at an all-time high of 29%. Depression causes considerable distress and functional impairment affecting quality of life, employment, and interpersonal relationships.
Leesa A, McBroom, Melissa, Timmons
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Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression

New England Journal of Medicine, 2022
Charles Debattista   +2 more
exaly  

Methimazole in treatment-resistant depression

Biological Psychiatry, 1992
R T, Joffe, W, Singer, A J, Levitt
openaire   +2 more sources

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