Results 81 to 90 of about 259,075 (330)

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Clinical and biological markers of electroconvulsive therapy effectiveness: a narrative review

Translational Psychiatry
Electroconvulsive therapy (ECT) is the most effective treatment for several particularly severe or pharmacotherapy-resistant psychiatric disorders, and a growing number of studies have investigated factors influencing the effectiveness of ECT.
David Zilles-Wegner, Iven-Alex von Mücke-Heim, Antoine Yrondi, Akihiro Takamiya   +3 more
doaj   +1 more source

Psychoanalytic and psychodynamic therapies for depression. The evidence base. [PDF]

, 2008
David Taylor, a consultant psychotherapist at the Tavistock & Portman NHS Foundation Trust (120 Belsize Lane, London NW3 5BA, UK. Email: dtaylor@tavi-port.nhs.uk), is the clinical lead of the Tavistock Adult Depression Study (a randomised controlled ...
Beutel, Churchill, Coryell, Crits-Christoph, Davanloo, David Taylor, Freud, Freud, Goldberg, Goldberg, Hirschfeld, Klein, Lambert, Luborsky, Mueller, Paykel, Robins, Roth, Weissman   +18 more
core   +1 more source

Treatment-Resistant Depression Revisited: A Glimmer of Hope

Journal of Personalized Medicine, 2021
Major Depressive Disorder (MDD) is a highly prevalent psychiatric disorder worldwide. It causes individual suffering, loss of productivity, increased health care costs and high suicide risk.
A. Halaris, Emilie Sohl, E. A. Whitham
semanticscholar   +1 more source

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones, Samuele Bonomi, Keith E. Stockerl‐Goldstein, Randall J. Bateman   +3 more
wiley   +1 more source

Molecular serum signature of treatment resistant depression [PDF]

, 2016
Rationale: A substantial number of patients suffering from major depressive disorder (MDD) do not respond to multiple trials of anti-depressants, develop a chronic course of disease and become treatment resistant.
Arolt, V, Bahn, S, Chan, MK, Cooper, JD, Grosse, L, Rothermundt, M, Ruland, T, Stocki, P   +7 more
core   +1 more source

Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial.

JAMA psychiatry, 2019
Importance Controlled studies have shown short-term efficacy of esketamine for treatment-resistant depression (TRD), but long-term effects remain to be established.
E. Daly, M. Trivedi, A. Janik, Honglan Li, Yun Zhang, Xiang Li, R. Lane, P. Lim, A. Duca, D. Hough, M. Thase, J. Zajecka, A. Winokur, I. Divacka, A. Fagiolini, W. Cubała, I. Bitter, P. Blier, R. Shelton, P. Molero, H. Manji, W. Drevets, Jaskaran Singh   +22 more
semanticscholar   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source

Overcoming the myths of esketamine administration: different and not difficult

Frontiers in Psychiatry, 2023
Intranasal esketamine for treatment-resistant depression has been introduced and approved by the FDA and EMA in 2019 and 2020, respectively. Since then, the administration practices were found different among countries. Major depression has a high impact
Florian Buchmayer, Siegfried Kasper
doaj   +1 more source

Moderators of the effects of exercise and manual therapy for people with knee and hip osteoarthritis: A secondary analysis of the MOA trial

Arthritis Care &Research, Accepted Article.
Objective This study aimed to investigate potential moderators influencing the effects of manual therapy and exercise therapy on pain and functional outcomes in individuals with knee and/or hip osteoarthritis, using data from the MOA trial. Design This is a secondary analysis of data from the MOA trial that compared the clinical effectiveness of manual
Daniel Cury Ribeiro, Sarah E. Lamb, J. Haxby Abbott   +2 more
wiley   +1 more source