Results 181 to 190 of about 75,341 (263)

Defining the Patient Journey and Identifying Digital Health Solutions in Treatment-Resistant Schizophrenia. [PDF]

open access: yesActas Esp Psiquiatr
Grasa E   +10 more
europepmc   +1 more source

Radiogenomics: Current Understandings and Future Perspectives

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Radiogenomics links imaging phenotypes with genetic variations, offering potential for comprehensive understanding, cost‐effective diagnosis, and prognosis prediction to advance personalized medicine. However, its clinical application remains limited by several challenges.
Xinyu Zhang   +8 more
wiley   +1 more source

Chlorpromazine versus placebo for schizophrenia [PDF]

open access: yes, 2014
Abrams   +486 more
core   +1 more source

Oligodendrocyte: Development, Plasticity, Biological Functions, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 2, February 2026.
The oligodendrocyte lineage and its roles in development, plasticity, and CNS homeostasis have been shown to have the potential to treat neurological diseases. However, the main obstacles to clinical translation, particularly in terms of BBB challenges and precise delivery.
Qiong Xiang   +6 more
wiley   +1 more source

C‐Reactive Protein and Neutrophil‐To‐Lymphocyte Ratio: Can They Be Used Interchangeably in Tracking Clozapine‐Related Inflammation?

open access: yesPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 2, February 2026.
ABSTRACT Background Clozapine initiation often triggers inflammatory responses that can alter metabolism via Cytochrome P450 1A2 (CYP1A2) suppression. Although C‐reactive protein (CRP) is the recommended marker, it may be unavailable in community settings.
Nicoline Bihelek   +3 more
wiley   +1 more source

Design of Experiments (DoE)‐Optimized Polymeric Oxytocin Nanoparticles for Enhanced Nose‐to‐Brain Delivery

open access: yesSmall, Volume 22, Issue 8, 6 February 2026.
Intranasal (IN) delivery of PEGylated PLGA nanoparticles (NPs) loaded with oxytocin (OT) (OT‐NP‐PEG) is investigated as a strategy to enhance OT transport to the brain for treating autism and other neuropsychiatric disorders. The optimized NP formulation demonstrates appropriate physicochemical characteristics, improved stability, and enhanced mucosal ...
Naveed Ahmad   +11 more
wiley   +1 more source

Single‐cell RNA sequencing revealed the T‐cell heterogeneity and exhaustion subsets of Helicobacter pylori‐induced gastritis‐to‐cancer transformation

open access: yesVIEW, Volume 7, Issue 1, February 2026.
H. pylori infection is a major cause of stomach cancer, but its effect on immune cells in tumors is unclear. Using single‐cell sequencing, we mapped the stomach tumor environment and discovered a specific exhausted T‐cell subtype, marked by the FYB1 gene, that is abundant in H. pylori‐positive tumors and linked to patient prognosis. Our findings reveal
Yanhui Yang   +22 more
wiley   +1 more source

Association Between Metabolic Syndrome, Obesity, and Cognitive Performances in Individuals With Bipolar Disorders: Cross‐Sectional and Longitudinal Analyses in the FACE‐BD Cohort

open access: yesActa Psychiatrica Scandinavica, Volume 153, Issue 2, Page 108-121, February 2026.
ABSTRACT Introduction Metabolic syndrome (MetS) has been suggested to be associated with cognitive impairments in bipolar disorder (BD); however, studies are limited by small sample sizes or cross‐sectional design. Our objective is to evaluate the cross‐sectional and longitudinal associations between MetS and cognitive performances in a large cohort of
I. Palimaru   +110 more
wiley   +1 more source

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