Adjuvant Mood Stabilisers for Long-Term Management of Treatment-Resistant Schizophrenia: A Case Report. [PDF]
Anyameluhor F, Elliott C.
europepmc +1 more source
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren +8 more
wiley +1 more source
Th1/Th17-linked transcription factors TBX21 and RORC were associated with clinical response to rituximab in treatment-resistant schizophrenia. [PDF]
Bylund S +4 more
europepmc +1 more source
Intranasal Mucosal Atomiser Devices: A Novel Harm Reduction Intervention
ABSTRACT Introduction Factors associated with diminished peripheral vein access, including age, prolonged history of injecting drug use and coadministration with other substances, are all increasing among people who inject drugs in Australia. This exposes individuals to increased risk of injecting related complications, including skin and soft tissue ...
Hayden Green +5 more
wiley +1 more source
Identifying Clinical Characteristics of Young People with Treatment-Resistant Schizophrenia Undergoing Community Initiation of Clozapine. [PDF]
Conaty O +5 more
europepmc +1 more source
Update of the EuroGuiDerm evidence‐based guideline for the treatment of acne—Short version
The 2025 EuroGuiDerm guideline update provides evidence‐based recommendations for acne management, addressing systemic antibiotics, systemic isotretinoin, hormonal therapies including spironolactone and contraceptives, and new topical agents. Key considerations include treatment duration, safety, pregnancy‐specific guidance and minimizing antibiotic ...
Alexander Nast +22 more
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Personalizing Clozapine in Treatment-Resistant Schizophrenia: The Role of MicroRNA Biomarkers-A Pilot Study. [PDF]
Sosin DN +7 more
europepmc +1 more source
GR‐A knockin mice were generated that express the classic full‐length glucocorticoid receptor (GR‐A) but lack the highly conserved translational isoforms GR‐B, GR‐C1, GR‐C2, GR‐C3, GR‐D1, GR‐D2, and GR‐D3 that have progressively shorter N‐terminal transactivation domains (NTDs).
Robert H. Oakley +8 more
wiley +1 more source
Neural substrates of treatment-resistant schizophrenia and the response to clozapine: A structural MRI study in a clinical setting. [PDF]
Masumo Y +12 more
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