Results 181 to 190 of about 59,572 (271)

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren   +8 more
wiley   +1 more source

Intranasal Mucosal Atomiser Devices: A Novel Harm Reduction Intervention

open access: yesDrug and Alcohol Review, Volume 45, Issue 5, July 2026.
ABSTRACT Introduction Factors associated with diminished peripheral vein access, including age, prolonged history of injecting drug use and coadministration with other substances, are all increasing among people who inject drugs in Australia. This exposes individuals to increased risk of injecting related complications, including skin and soft tissue ...
Hayden Green   +5 more
wiley   +1 more source

Update of the EuroGuiDerm evidence‐based guideline for the treatment of acne—Short version

open access: yesJournal of the European Academy of Dermatology and Venereology, Volume 40, Issue 7, Page 1162-1172, July 2026.
The 2025 EuroGuiDerm guideline update provides evidence‐based recommendations for acne management, addressing systemic antibiotics, systemic isotretinoin, hormonal therapies including spironolactone and contraceptives, and new topical agents. Key considerations include treatment duration, safety, pregnancy‐specific guidance and minimizing antibiotic ...
Alexander Nast   +22 more
wiley   +1 more source

Personalizing Clozapine in Treatment-Resistant Schizophrenia: The Role of MicroRNA Biomarkers-A Pilot Study. [PDF]

open access: yesCurr Issues Mol Biol
Sosin DN   +7 more
europepmc   +1 more source

Glucocorticoid Receptor Translational Isoforms Generate Unique Glucocorticoid Responses in the Mouse Brain

open access: yesThe FASEB Journal, Volume 40, Issue 12, 30 June 2026.
GR‐A knockin mice were generated that express the classic full‐length glucocorticoid receptor (GR‐A) but lack the highly conserved translational isoforms GR‐B, GR‐C1, GR‐C2, GR‐C3, GR‐D1, GR‐D2, and GR‐D3 that have progressively shorter N‐terminal transactivation domains (NTDs).
Robert H. Oakley   +8 more
wiley   +1 more source

Neural substrates of treatment-resistant schizophrenia and the response to clozapine: A structural MRI study in a clinical setting. [PDF]

open access: yesPLoS One
Masumo Y   +12 more
europepmc   +1 more source

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