Results 191 to 200 of about 75,341 (263)

Dihydrotestosterone and Finasteride Effects on Alcohol Cue‐Elicited Brain Activity in Males With Heavy Episodic Drinking

Addiction Biology, Volume 31, Issue 2, February 2026.
In a randomized, double‐blind, placebo‐controlled crossover study, we investigated whether finasteride‐induced reduction of dihydrotestosterone alters alcohol cue‐elicited brain activity and craving in males with heavy episodic drinking. Although dihydrotestosterone concentrations were not associated with neural cue reactivity, finasteride increased ...
Rafat Boroumand‐Jazi, Sabine Hoffmann, Iris Reinhard, Patrick Bach, Wolfgang H. Sommer, Marlene Kundlacz, Christian P. Müller, Matthias Reichl, Haoye Tan, Leonard P. Wenger, Anne Beck, Sabine Vollstädt‐Klein, Falk Kiefer, Christiane Mühle, Sarah Gerhardt, Bernd Lenz   +15 more
wiley   +1 more source

A complex network perspective on brain disease

Biological Reviews, Volume 101, Issue 1, Page 364-399, February 2026.
ABSTRACT If brain anatomy and dynamics have a complex network structure as it has become standard to posit, it is reasonable to assume that such a structure should play a key role not only in brain function but also in brain dysfunction. However, exactly how network structure is implicated in brain damage and whether at least some pathologies can be ...
David Papo, Javier M. Buldú
wiley   +1 more source

Drug Repurposing Screen Identifies Pimozide as a ROS‐Inducing Therapy With Anti‐Tumor Efficacy in HNSCC PDX Models

Cancer Science, Volume 117, Issue 2, Page 511-521, February 2026.
A drug repurposing screen for reactive oxygen species (ROS)‐inducing compounds identified Pimozide as a potent anti‐tumor agent in head and neck squamous cell carcinoma (HNSCC) patient‐derived xenograft (PDX) models. Combined treatment with paclitaxel markedly reduced undifferentiated tumor cells.
Shogo Okazaki, Shintaro Nakamura, Tomoya Soma, Momoko Yoshikawa, Seiji Asoda, Yurika Nakajima, Kenji Tsuchihashi, Mitsuyo Ohmura, Ryo Goitsuka, Kenichi Imai, Hideyuki Saya, Osamu Nagano, Hiroyuki Ozawa   +12 more
wiley   +1 more source

Peripheral biomarkers and the philosophy of precision in treatment-resistant schizophrenia. [PDF]

Neurosci Appl
Jerotic S.
europepmc   +1 more source

D1/D5 receptor activation promotes long‐term potentiation and synaptic tagging/capture in hippocampal area CA2

The FEBS Journal, Volume 293, Issue 3, Page 766-780, February 2026.
Activation of dopamine receptor D1 (D1R) stimulates PKA and ERK pathways via dissociation of stimulatory and olfactory G protein alpha subunits (Gαs/olf). PKA relieves striatal‐enriched protein tyrosine phosphatase (STEP) inhibition of ERK, promoting cyclic adenosine monophosphate response element‐binding protein (CREB)‐driven transcription of ...
Kevin Chua, Yee Song Chong, Sreedharan Sajikumar   +2 more
wiley   +1 more source

Co‐Designing End‐of‐Life Care for People With Pre‐Existing Severe Mental Illness: Insights From Multiple Stakeholder Consultations

International Journal of Mental Health Nursing, Volume 35, Issue 1, February 2026.
ABSTRACT People with severe mental illness (SMI) experience significant health disparities, and their end‐of‐life care remains underdeveloped. Employing a co‐design approach, this study engaged a range of stakeholders in Hong Kong, including people with SMI, their family members and professionals in mental health and palliative care, to identify ...
Jialiang Cui, Cong Zheng, Cheryl Chi‐Yan Yeung, Helen Yue‐lai Chan   +3 more
wiley   +1 more source

Non-Clozapine interventions in treatment-resistant schizophrenia: a systematic review and meta-analysis. [PDF]

Mol Psychiatry
Carr R, Cannon A, Finelli V, Bukala B, Cimen Y, Filipova P, Cummings C, Pillinger T, Howes OD, McCutcheon RA.   +9 more
europepmc   +1 more source

The Effect of Digital Cognitive Behavioural Therapy for Insomnia in People With Co‐Morbid Insomnia and Sleep Apnoea (COMISA): A Pilot Randomised Controlled Trial

Journal of Sleep Research, Volume 35, Issue 1, February 2026.
ABSTRACT Co‐morbid insomnia and sleep apnoea (COMISA) is a prevalent and debilitating condition. Cognitive behavioural therapy for insomnia (CBTi) is an effective but largely inaccessible treatment in patients with COMISA. We aimed to test a self‐guided interactive digital CBTi program tailored for COMISA and insomnia alone.
Alexander Sweetman, Cele Richardson, Allan Smith, Chelsea Reynolds   +3 more
wiley   +1 more source

Effectiveness of deep brain stimulation in alleviating treatment-resistant schizophrenia: a systematic review. [PDF]

Eur J Transl Myol
Khosravi M.
europepmc   +1 more source