Results 101 to 110 of about 13,587,543 (295)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Scientific ReportsTo enhance attention on low-income patients with hemophilia, it is essential to urge governments and coagulation factor manufacturers to increase their investment in hemophilia care.
Jie Wang +7 more
doaj +1 more source
Sex offender treatment providers: registry.
, 1996 Directory of mental health professionals in Texas who meet the minimum requirements for training and experience regarding knowledge and experience with the sex offender ...
Texas. Council on Sex Offender Treatment.
core
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Sex offender treatment providers: registry.
, 1991 Directory of mental health professionals in Texas who meet the minimum requirements for training and experience regarding knowledge and experience with the sex offender ...
Texas. Council on Sex Offender Treatment.
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Radiation OncologyBackground The expanding use of medical diagnostics and radiotherapy has increased public exposure to low dose ionizing radiation (LDIR). A more clinically pressing concern, however, is the unintended irradiation of normal tissues adjacent to the ...
Xin Lan +11 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
UK Alcohol Treatment trial: client-treatment matching effects
, 2008 Aim To test a priori hypotheses concerning client–treatment matching in the treatment of alcohol problems and to evaluate the more general hypothesis that client–treatment matching adds to the overall effectiveness of treatment. Design Pragmatic,
Raistrick, Duncan +34 more
core +1 more source
EGFR exon 20 insertions in advanced non-small cell lung cancer: A new history begins
, 2020 Although targeted therapy is standard of care in a large subset of oncogenic addicted non-small cell lung cancers (NSCLC), until recently, this therapeutic approach has not been feasible for all genomic alterations such as for those tumors harboring ...
Hendriks, Lizza E.L +2 more
core +1 more source