Results 111 to 120 of about 13,587,543 (295)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Effectiveness of Fu’s Subcutaneous Needling for Residual Pain After Percutaneous Vertebral Augmentation in Osteoporotic Vertebral Compression Fractures: A Randomized Clinical Trial Protocol

Journal of Pain Research
Qiong Wang,1,* Zhengqiang Ren,1,* Binru Wang,1,* Juan Du,1,* Xinming Li,1 Jianjiao Mou2 1Department of Pain Treatment, Suining Central Hospital, Suining, People’s Republic of China; 2Department of Rehabilitation Medicine ...
Wang Q, Ren Z, Wang B, Du J, Li X, Mou J
doaj  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Risk prediction model for overall survival in lung cancer based on inflammatory and nutritional markers

Scientific Reports
This study aims to develop a multidimensional risk prediction model, identify characteristic inflammation-nutrition biomarkers, and optimize clinical decision-making.
Hongqi Zhou, Weiyun Jin, Lindi Li, Xiangwen Nie, Weiwei Wu, Ran Chen, Qizhen Xie, Haixia Wu, Weiwei Jiang, Min Tang, Jinhai Wang, Maoyuan Wang   +11 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Development of a nurse-led mHealth intervention framework for patients with chronic diseases: A systematic review and Delphi study

Digital Health
Objective mHealth is increasingly becoming popular and useful for managing chronic diseases. Nurse-led mHealth services offer a patient-centred perspective, but many existing solutions lack a robust empirical foundation.
Jianing Hua, Dan Sun, Huihong Wang, Jiang Chang, Guo Fei, Qing Zhou, Ning Hui, Danfeng Gu, Lihong Zhu   +8 more
doaj   +1 more source

Does acute-phase acupuncture at Hegu (LI04) promote facial nerve regeneration and upregulation of the PI3K/Akt/mTOR pathway? A hypothesis-generating study in a rabbit crush injury model

Frontiers in Neurology
This study used the rabbit facial nerve crush injury model to investigate the time-dependent effects of acupuncture at Hegu (LI04) on facial nerve regeneration and regulatory role of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt ...
Jin Song, Jianyun Zhang, Xinsheng He, Zhichun Zhu, Bingyan Liu, Yang Liu, Chen Liang, Binbin Jiang, Kesheng Zhang   +8 more
doaj   +1 more source

Comparazion of dual nucleoside-analogue reverse-transcriptase inhibitor regimens with and without nelfinavir in children with HIV-1 who have not previously been treated: the PENTA 5 randomised trial.

, 2002
INTRODUCTION: Treatment options for children with HIV-1 are limited. We aimed to compare activity and safety of three dual-nucleoside analogue reverse-transcriptase inhibitor (NRTI) regimens with or without a protease inhibitor in previously untreated ...
DUSE, MARZIA, Paediatric European Network for Treatment of AIDS   +1 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source