Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
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The influence of tumor- and treatment-related factors on the development of local recurrence in osteosarcoma after adequate surgery. An analysis of 1355 patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols [PDF]
, 2010 Dimosthenis Andreou +19 more
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FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
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Neurology and TherapyIntroduction High-dose intravenous methylprednisolone (IVMP) is effective in treating generalized myasthenia gravis (gMG), but early-stage transient aggravation and MG crisis can occur.
Shanshan Gu +9 more
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Combination Cancer Treatment: Using Engineered DNAzyme Molecular Machines for Dynamic Inter‐ and Intracellular Regulation [PDF]
, 2022 Ruo‐Can Qian +6 more
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LAMELAR CORNEAL TRANSPLANTATION IN A DOG FOR SURGICAL TREATMENT OF CORNEA DEEP ULCER WITH DESCEMETOCELE. [PDF]
, 2018 Corneal transplantation is a procedure indicated for surgical treatment of several corneal diseases, requiring replacement of the affected tissues1,2,3,4.
Alexandre, N. +3 more
core
The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
Criteria for expedited antiretroviral initiation and emergency triage
Southern African Journal of HIV Medicine, 2009 SANAC Treatment Task Team
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CT findings of pulmonary artery aneurysms during treatment for Behçet's disease. [PDF]
, 1999 Mehtap Tunacı +5 more
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The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
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