Results 41 to 50 of about 7,725,061 (294)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Evaluating the equity impact and cost-effectiveness of digital adherence technologies with differentiated care to support tuberculosis treatment adherence in Ethiopia: protocol and analysis plan for the health economics component of a cluster randomised trial

Trials, 2023
Background Tuberculosis remains a leading infectious cause of death in resource-limited settings. Effective treatment is the cornerstone of tuberculosis control, reducing mortality, recurrence and transmission.
Nicola Foster, Amare W. Tadesse, Christopher Finn McQuaid, Lara Gosce, Tofik Abdurhman, Demelash Assefa, Ahmed Bedru, Rein M. G. J. Houben, Kristian van Kalmthout, Taye Letta, Zemedu Mohammed, Job van Rest, Demekech G. Umeta, Gedion T. Weldemichael, Hiwot Yazew, Degu Jerene, Matthew Quaife, Katherine L. Fielding   +17 more
doaj   +1 more source

Costs and adherence to antiretroviral treatment

Farmacia Hospitalaria (English Edition), 2010
To develop a system of data management that allows us to estimate the comparative effectiveness of the various antiretroviral treatment (ART) regimens.Retrospective observational study in patients infected with HIV with stable ART. Adherence to treatment and unit cost for each patient's treatment was determined. The cost/patient/day was calculated and,
J M, Ventura-Cerdá, D, Ayago-Flores, E, Vicente-Escrig, S, Mollá-Cantavella, M, Alós-Almiñana   +4 more
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Antiretroviral treatment adherence among HIV patients in KwaZulu-Natal, South Africa. [PDF]

, 2010
BACKGROUND: Successful antiretroviral treatment is dependent on sustaining high rates of adherence. In the southern African context, only a handful of studies (both quantitative and qualitative) have looked at the determinants including a health ...
Ramlagan Shandir, Shandir Ramlagan, Ramlagan, Shandir, Anderson Jane, Anderson, Jane, Peltzer Karl, Karl Peltzer, Natalie Friend-du Preez, Friend-du Preez Natalie, Peltzer, Karl, Friend-du Preez, Natalie, Jane Anderson   +11 more
core   +2 more sources

Factors Associated With Adherence to Treatment Regimen in Patients With Type 2 Diabetes in Sari, Iran

نشریه پرستاری ایران, 2022
Background & Aims: As a chronic disease with many complications, diabetes requires adherence to treatment regimen. Despite the importance of adherence, it is not done completely in these patients.
Alice Khachian, Naima Seyedfatemi, Hamid Sharif Nia, Mehrnegar Amiri   +3 more
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Determinants of antiretroviral adherence among HIV positive children and teenagers in rural Tanzania = a mixed methods study [PDF]

, 2015
BackgroundAround 3.3 million children worldwide are infected with HIV and 90% of them live in sub-Saharan Africa. Our study aimed to estimate adherence levels and find the determinants, facilitators and barriers of ART adherence among children and ...
Emilio Letang, Lars Henning, Eveline Geubbels, Franzeck, Fabian C., Glass, Tracy R, Nyogea, Daniel, Marcel Tanner, Fabian C Franzeck, Glass, Tracy R., Mtenga, Sally, Letang, Emilio, Sally Mtenga, Henning, Lars, Geubbels, Eveline, Tracy R Glass, Franzeck, Fabian C, Daniel Nyogea, Tanner, Marcel   +17 more
core   +2 more sources

Treatment compliance among previously diagnosed type 2 diabetics in a rural area in Southern India

Journal of Family Medicine and Primary Care, 2019
Background: Treatment adherence will help to achieve good glycemic control among diabetics and will lead to lesser complications associated with the disease.
Satyajit Pattnaik, Samina Mustafa Ausvi, Akshay Salgar, Dhananjaya Sharma   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source