Results 121 to 130 of about 10,822,491 (313)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Outcome specific optimal systolic blood pressure targets in high risk patients, balancing cardiovascular benefits, renal risks, and cancer prevention: meta-analysis of randomised controlled trials

BMJ Medicine
Objective To directly compare the efficacy and safety of different intensive systolic blood pressure targets (<120 or <130 mm Hg) versus usual care on cardiovascular and renal outcomes.Design Meta-analysis of randomised controlled trials.Data ...
Yuanyuan Zhang, Yu Huang, Yiwei Zhang, Xianhui Qin, Yanjun Zhang, Sisi Yang, Xiaoqin Gan, Fan Fan Hou, Yiting Wu   +8 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Illness representations, treatment beliefs and the relationship to self-care in heart failure [PDF]

, 2011
Purpose The purpose of this study was to explore the beliefs people with heart failure hold about their illness and its treatment and to determine any relationships between these beliefs and self-care using the Common Sense Model (CSM) of illness ...
MacInnes, J.
core  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Heart failure treatment in the last years of life : A nationwide study of 364 000 individuals

AIMS: In patients with heart failure, treatment patterns in the last years of life have not been assessed at large scale. We aimed to assess whether heart failure treatment patterns up to 5 years prior to death changed over time.
Lindholm, Daniel P, Gustafsson, Stefan, Sundström, Johan, Cars, Thomas, Gustafsson, Stefan,, Lindholm, Daniel P,, Sundström, Johan,, Cars, Thomas,   +7 more
core   +1 more source

Advanced heart failure - treatment options beyond medical management

, 2011
Improvement of heart failure therapy has led to a far better survival and quality of life of patients. Treatment of the underlying disease, patient education and improvement of compliance and consequent upgrading of medical heart failure therapy often ...
Mohacsi, P, Bösch, C, Signorell, J, Signorell, Janko, Martinelli, M, Bösch, Claudia, Mohacsi, Paul, Martinelli, Michele V, Mohacsi P, Bösch C, Signorell J, Martinelli MV, Signorell, Jan, Martinelli, Michele   +13 more
core   +1 more source

Causes of Botulinum Toxin Treatment Failure

, 2021
Purpose: The purpose of this article is to review the cause of botulinum toxin (BT) failure and determine the ways to minimize the risks of its occurrence.
Shtefan, Valentina
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Diagnosing Depression in Congestive Heart Failure

, 2011
Depression is an all too common occurrence in heart failure patients. Depressive symptoms, however, sometimes are confused with the physical repercussions of heart failure.
Tara Mayes, Saveanu, Radu V, Mayes, Tara, Radu V. Saveanu   +3 more
core   +1 more source