Results 111 to 120 of about 252,808 (266)

Illness representations, treatment beliefs and the relationship to self-care in heart failure [PDF]

, 2011
Purpose The purpose of this study was to explore the beliefs people with heart failure hold about their illness and its treatment and to determine any relationships between these beliefs and self-care using the Common Sense Model (CSM) of illness ...
MacInnes, J.
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Emergency Treatment of Failure

, 2017
Heart failure is a burden to the health care system. With the high mortality and incident mortality rate, physicians must work dutifully and meticulously to ensure improvement of patient conditions.
Braimoh, Grace A
core  

Statistical Analysis of Treatment Planning Parameters for Prediction of Delivery Quality Assurance Failure for Helical Tomotherapy

, 2020
Purpose: This study aimed to investigate the parameters with a significant impact on delivery quality assurance (DQA) failure and analyze the planning parameters as possible predictors of DQA failure for helical tomotherapy.
Kim, Yong Bae, Cho, Jaeho, Kim, Hojin, Kang, Hyokyeong, Kim, Dong Wook, Cho, Min-Seok, Lee, Ho, Park, Kwangwoo, Han, Min Cheol, Park, Byung Hun, Kim, Jihun, Lee, Young Hyun, Chang, Kyung Hwan, Kim, Jin Sung, Hong, Chae-Seon   +14 more
core   +1 more source

Association of Urinary Soluble CD163 With Response to Immunosuppressive Therapy and Renal Relapse in IgAN

Kidney International Reports
Introduction: The absence of a dynamic, noninvasive biomarker to monitor intrarenal immunologic activity during and after immunosuppressive therapy limits patient-specific risk stratification and timely treatment decisions in IgA nephropathy (IgAN).
Hao Zhao, Zishu Zhan, Tong Lin, Yongyi Pan, Shuling Yuan, Jingxin Huang, Ling Jia, Di Xie   +7 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

First-line antiretroviral treatment failure and associated factors in HIV patients at University of Gondar Teaching Hospital, Gondar, Northwest Ethiopia

, 2016
Mohammed Biset Ayalew,1 Dawit Kumilachew,2 Assefa Belay,3 Samson Getu,4 Derso Teju,4 Desalegn Endale,4 Yemisirach Tsegaye,4 Zebiba Wale4 1Department of Clinical Pharmacy, 2Department of Pharmaceutics, 3Department of Pharmacology, 4School of Pharmacy ...
Wale Z, Belay A, Tsegaye Y, Teju D, Kumilachew D, Ayalew MB, Getu S, Endale D   +7 more
core  

Telaprevir or boceprevir based therapy for chronic hepatitis C infection: Development of resistance-associated variants in treatment failure

, 2014
The use of triple-therapy, pegylated-interferon, ribavirin and either of the first generation hepatitis C virus (HCV) protease inhibitors telaprevir or boceprevir, is the new standard of care for treating genotype 1 chronic HCV.
Garcia-Diaz, A., Dusheiko, G., Labbett, W., Velazquez, C., Macartney, M.J., Trembling, P., Haque, T., Rosenberg, W.M., Booth, C., Irish, D., Bridge, S.H., Tanwar, S., Smith, C., Jacobs, M., McCormick, A.L.   +14 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A Novel 10‐Protein Score for Liver Fat Content Predicts Cardiovascular‐Kidney‐Metabolic Disease Risk

Advanced Science
Liver fat content (LFC) is a key biomarker for cardiovascular‐kidney‐metabolic (CKM), yet noninvasive assessment remains challenging. It aims to develop a plasma proteomic‐based LFC score to predict MRI‐derived proton density fat fraction (MRI‐PDFF ...
Xiaoqin Gan, Yuanxiu Wei, Yiting Wu, Xinyue Su, Gangling Wang, Sisi Yang, Ziliang Ye, Yanjun Zhang, Hao Xiang, Yu Huang, Yiwei Zhang, Yuanyuan Zhang, Xianhui Qin   +12 more
doaj   +1 more source