Results 91 to 100 of about 252,808 (266)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Risk and Temporal Changes of Heart Failure Among 5-Year Childhood Cancer Survivors: a DCOG-LATER Study

, 2019
Background Heart failure is one of the most important late effects after treatment for cancer in childhood. The goals of this study were to evaluate the risk of heart failure, temporal changes by treatment periods, and the risk factors for heart failure ...
van der Pal, Helena J. H., van den Berg, Marleen H., Loonen, Jacqueline J., Geskus, Ronald B., van Dulmen-den Broeder, Eline, Kremer, Leontien C. M., van Dalen, Elvira C., Neggers, Sebastian J. C. M. M., van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M., Ronckers, C. cile M., van Leeuwen, Flora E., Feijen, E. A. M. Lieke, Bresters, Dorine, Versluys, A. B. Birgitta, Kok, Wouter E. M., Font-Gonzalez, Anna, Tissing, Wim J. E.   +17 more
core   +1 more source

Urate-lowering therapy and kidney outcomes in patients with chronic kidney disease and hyperuricemia

Signal Transduction and Targeted Therapy
Hyperuricemia is considered a modifiable risk factor for the development and progression of chronic kidney disease (CKD). There remains controversy over the effects of urate-lowering therapy (ULT) on kidney outcomes in patients with CKD and hyperuricemia.
Sheng Nie, Shiyu Zhou, Ruixuan Chen, Lantian Li, Yinfang Sun, Jiao Liu, Luhua Jin, Xian Shao, Mingzhen Pang, Licong Su, Fan Luo, Xin Xu, Fan Fan Hou   +12 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The brain in heart failure [PDF]

, 2004
After atrial fibrillation, heart failure is the second most frequent cardiac association of stroke. Deteriorating left ventricular systolic function appears to increase the risk of cardioembolic stroke in heart failure.
Pullicino, Patrick
core  

Creatinine promotes adipose tissue wasting in chronic kidney disease via creatine and futile creatine cycle

Molecular Metabolism
Objective: Cachexia in chronic kidney disease (CKD) is a wasting syndrome. The futile creatine cycle (FCC) contributes to energy waste in adipocytes. Creatinine is metabolite of creatine.
Jingwen Fang, Xianfen Huang, Chanchan Guo, Ting Chen, Yubing Chen, Xiaobing Yang, Min Zheng, Hanying Ding   +7 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

HIV-associated multi-centric Castleman’s disease with multiple organ failure: cuccessful treatment with rituximab

, 2010
Introduction: Multicentric Castleman's Disease (MCD), a lymphoproliferative disorder associated with Human Herpes Virus-8 (HHV-8) infection, is increasing in incidence amongst HIV patients.
Johns, RH, Lipman, M, Agarwal, B, Cwynarski, K, Doyle, T, Isaacson, PG, Cleverley, JR, Shaw, S   +7 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Outcome specific optimal systolic blood pressure targets in high risk patients, balancing cardiovascular benefits, renal risks, and cancer prevention: meta-analysis of randomised controlled trials

BMJ Medicine
Objective To directly compare the efficacy and safety of different intensive systolic blood pressure targets (<120 or <130 mm Hg) versus usual care on cardiovascular and renal outcomes.Design Meta-analysis of randomised controlled trials.Data ...
Yuanyuan Zhang, Yu Huang, Yiwei Zhang, Xianhui Qin, Yanjun Zhang, Sisi Yang, Xiaoqin Gan, Fan Fan Hou, Yiting Wu   +8 more
doaj   +1 more source