Results 91 to 100 of about 8,931,330 (313)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Risk and Temporal Changes of Heart Failure Among 5-Year Childhood Cancer Survivors: a DCOG-LATER Study

, 2019
Background Heart failure is one of the most important late effects after treatment for cancer in childhood. The goals of this study were to evaluate the risk of heart failure, temporal changes by treatment periods, and the risk factors for heart failure ...
van der Pal, Helena J. H., van den Berg, Marleen H., Loonen, Jacqueline J., Geskus, Ronald B., van Dulmen-den Broeder, Eline, Kremer, Leontien C. M., van Dalen, Elvira C., Neggers, Sebastian J. C. M. M., van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M., Ronckers, C. cile M., van Leeuwen, Flora E., Feijen, E. A. M. Lieke, Bresters, Dorine, Versluys, A. B. Birgitta, Kok, Wouter E. M., Font-Gonzalez, Anna, Tissing, Wim J. E.   +17 more
core   +1 more source

Q63, a novel DENV2 RdRp non-nucleoside inhibitor, inhibited DENV2 replication and infection

Journal of Pharmacological Sciences, 2018
Dengue virus (DENV) annually infects 400 million people worldwide. Unfortunately, there is lack of widely protective vaccine or drugs against DENV. The viral RNA-dependent RNA polymerase (RdRp) of NS5 protein is highly conserved among different DENV ...
Xingang Yao, Songxin Guo, Wenyu Wu, Jinan Wang, Shengen Wu, Shijun He, Yihong Wan, Kutty Selva Nandakumar, Xiaoguang Chen, Ning Sun, Qiuhua Zhu, Shuwen Liu   +11 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Creatinine promotes adipose tissue wasting in chronic kidney disease via creatine and futile creatine cycle

Molecular Metabolism
Objective: Cachexia in chronic kidney disease (CKD) is a wasting syndrome. The futile creatine cycle (FCC) contributes to energy waste in adipocytes. Creatinine is metabolite of creatine.
Jingwen Fang, Xianfen Huang, Chanchan Guo, Ting Chen, Yubing Chen, Xiaobing Yang, Min Zheng, Hanying Ding   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Pharmacological treatment of acute decompensated heart failure

, 2019
The number of patients being hospitalized for acute decompensated heart failure (ADHF) is growing in the United States. The increasing prevalence of heart failure is due to an increased number of older individuals, as well as improved treatment for ...
Roojee, Majidah Umme Kulsum
core  

Estimated glucose disposal rate outperforms conventional insulin resistance indices in predicting acute kidney injury risk among individuals with diabetes and prediabetes

Diabetology & Metabolic Syndrome
Background Acute kidney injury (AKI) is a major global health concern, particularly in individuals with diabetes or prediabetes. While insulin resistance (IR) is implicated in AKI pathogenesis, the relationship between comprehensive IR measures ...
Jinsheng Mai, Yiting Wu, Yiwei Zhang, Yanjun Zhang, Sisi Yang, Xianhui Qin, Yuanyuan Zhang, Jianping Jiang   +7 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source