Results 71 to 80 of about 8,931,330 (313)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A systematic review on using intervention mapping to guide behavioral interventions for improving stroke patient outcomes

Frontiers in Medicine
BackgroundFunctional recovery after stroke is substantially dependent on systematic, evidence-based behavioral interventions. Intervention Mapping (IM), as a structured framework for intervention development, has demonstrated favorable outcomes across ...
Jinxian Yang, Jinxian Yang, Jianing Liu, Xiaoxia Zeng, Fan Yang, Hui Zhang, Yongxia Ding   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The COACH risk engine: a multistate model for predicting survival and hospitalization in patients with heart failure [PDF]

, 2012
Aims: Several models for predicting the prognosis of heart failure (HF) patients have been developed, but all of them focus on a single outcome variable, such as all-cause mortality.
Postmus, Douwe; id_orcid, Buskens, Erik; id_orcid, Harjola, Veli-Pekka,, Lewsey, James, Postmus, D., Postmus, Douwe, Hans L. Hillege, Lassus, Johan,, Hillege, Hans L.,, James Lewsey, Luttik, Marie Louise, van Veldhuisen, Dirk J.,, Harjola, V.P., Hillege, Hans L., Nieminen, M.S., Lewsey, James,, Mebazaa, Alexandre,, Veli‐Pekka Harjola, van Veldhuisen, Dirk J., Harjola, Veli-Pekka, Markku S. Nieminen, Buskens, Erik,, Luttik, Marie Louise,, Jaarsma, Tiny,, Alexandre Mebazaa, Buskens, E., Douwe Postmus, van Veldhuisen, D.J., Hillege, H.L., Johan Lassus, Buskens, Erik, Erik Buskens, Postmus, Douwe,, Marie Louise Luttik, Nieminen, Markku S., Lassus, J., Mebazaa, A., Jaarsma, Tiny, Jaarsma, T., Lassus, Johan, Dirk J. van Veldhuisen, Nieminen, Markku S.,, Luttik, M.L., Tiny Jaarsma, Lewsey, J., Mebazaa, Alexandre   +45 more
core   +2 more sources

Biofeedback in the treatment of heart failure

Cleveland Clinic Journal of Medicine, 2010
Biofeedback training can be used to reduce activation of the sympathetic nervous system (SNS) and increase activation of the parasympathetic nervous system (PNS). It is well established that hyperactivation of the SNS contributes to disease progression in chronic heart failure. It has been postulated that underactivation of the PNS may also play a role
Michael G, McKee, Christine S, Moravec
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Dynamic skeletal muscle loss and its predictive role on 90-day mortality in patients with acute-on-chronic liver failure

Frontiers in Nutrition
BackgroundLow skeletal muscle mass is an independent risk factor for increased mortality in patients with acute-on-chronic liver failure (ACLF). However, no study has evaluated the temporal changes in muscle mass during the course of ACLF.
Nan Geng, Ming Kong, Jiateng Zhang, Manman Xu, Huina Chen, Huina Chen, Wenyan Song, Yu Chen, Zhongping Duan   +8 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Impella RP as a bridge to cardiac transplant for refractory late right ventricular failure in setting of left ventricular assist device

ESC Heart Failure, 2020
Right ventricular (RV) failure remains a major complication after surgical implantation of a left ventricular assist device (LVAD). While the use of a percutaneous RV assist device has been described as a short‐term bridge to recovery in end‐stage heart ...
Varinder Kaur Randhawa, Karlee Hoffman, Ashley Bock, Pavan Bhat, Laura Young, Jeffrey Rossi, Joseph Campbell, Corrine Bott‐Silverman, Edward G. Soltesz, Michael Z.Y. Tong, Shinya Unai, Ravi Nair, Jerry D. Estep, Antonio L. Perez   +13 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source