Results 81 to 90 of about 8,931,330 (313)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Association of high-density lipoprotein cholesterol lipid with peritoneal dialysis related peritonitis

BMC Nephrology
Background The relationship between high-density lipoprotein cholesterol (HDL-C) concentrations and the risk of peritoneal dialysis-related peritonitis (PDRP) remains unclear.
Jinsheng Mai, Yiting Wu, Yiwei Zhang, Yanjun Zhang, Sisi Yang, Xianhui Qin, Yuanyuan Zhang, Jianping Jiang   +7 more
doaj   +1 more source

Oridonin as a novel KDM5C inhibitor alleviates clonal hematopoiesis-induced cardiac aging via H3K4me3-dependent SASP suppression

Acta Pharmaceutica Sinica B
TET2-mediated clonal hematopoiesis of indeterminate potential (CHIP) is a known cardiovascular risk factor, but its role in cardiac aging and potential for pharmacological intervention remain unclear.
Xingling Chen, Qiangqiang Zhao, Linhuang Chen, Shengrong Lin, Bin Mai, Xingling He, Xiaojiao Zhang, Jiahui Chen, Sijing Li, Ziru Li, Hua Zhang, Yuehui Zhou, Xiaofang Li, Huili Liao, Taochun Ye, Shuning Sun, Zhongqi Yang, Shihao Ni, Lu Lu   +18 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The successful treatment of hypercapnic respiratory failure with oral modafinil

, 2014
Helen Parnell,1 Ginny Quirke,1 Sally Farmer,1 Sumbo Adeyemo,2 Veronica Varney11Respiratory Department, 2Pharmacy Department, St Helier Hospital, Carshalton, Surrey, UKAbstract: Hypercapnic respiratory failure is common in advanced chronic obstructive ...
Farmer S, Parnell H, Quirke G, Adeyemo S, Varney V   +4 more
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Brachial pulse pressure in acute heart failure. Results of the Heart Failure Registry [PDF]

, 2019
[Abstract] Aims To investigate the still uncertain independent prognostic impact of pulse pressure (PP) in acute heart failure (HF), in particular across the left ventricular ejection fraction (EF) phenotypes, and the potential contribution of PP in ...
Macarie, Cezar,, Laroche, Cécile, Bonapace, Stefano,, Maggioni, Aldo P.,, Crespo-Leiro, Maria G., Ulf Dahlström, Maggioni, Aldo P, Andrea Rossi, Piepoli, Massimo F.,, Andrew J.S. Coats, Pier Luigi Temporelli, Maria G. Crespo‐Leiro, Malek, Filip, Tavazzi, Luigi,, Temporelli, Pier Luigi, Crespo-Leiro, María Generosa, Rossi, Andrea,, Rossi, Andrea, Stefano Bonapace, Cécile Laroche, Crespo-Leiro, Maria G.,, Bonapace, Stefano, Malek, Filip,, Dahlström, Ulf, Temporelli, Pier Luigi,, Coats, Andrew J S, Massimo F. Piepoli, Piepoli, Massimo F, Macarie, Cezar, Coats, Andrew J. S.,, Coats, Andrew J. S., Laroche, Cecile,, Filip Malek, Crespo Leiro, Marisa, Cezar Macarie, Luigi Tavazzi, Maggioni, Aldo P., Dahlström, Ulf,, Tavazzi, Luigi, Aldo P. Maggioni, Piepoli, Massimo F.   +40 more
core   +1 more source

Urate-lowering therapy and kidney outcomes in patients with chronic kidney disease and hyperuricemia

Signal Transduction and Targeted Therapy
Hyperuricemia is considered a modifiable risk factor for the development and progression of chronic kidney disease (CKD). There remains controversy over the effects of urate-lowering therapy (ULT) on kidney outcomes in patients with CKD and hyperuricemia.
Sheng Nie, Shiyu Zhou, Ruixuan Chen, Lantian Li, Yinfang Sun, Jiao Liu, Luhua Jin, Xian Shao, Mingzhen Pang, Licong Su, Fan Luo, Xin Xu, Fan Fan Hou   +12 more
doaj   +1 more source

Heart Failure: Gaps in Knowledge and Failures in Treatment

PLoS Medicine, 2014
Please see later in the article for the Editors' Summary.
openaire   +4 more sources