Results 81 to 90 of about 10,822,491 (313)

Telaprevir or boceprevir based therapy for chronic hepatitis C infection: Development of resistance-associated variants in treatment failure

, 2014
The use of triple-therapy, pegylated-interferon, ribavirin and either of the first generation hepatitis C virus (HCV) protease inhibitors telaprevir or boceprevir, is the new standard of care for treating genotype 1 chronic HCV.
Garcia-Diaz, A., Dusheiko, G., Labbett, W., Velazquez, C., Macartney, M.J., Trembling, P., Haque, T., Rosenberg, W.M., Booth, C., Irish, D., Bridge, S.H., Tanwar, S., Smith, C., Jacobs, M., McCormick, A.L.   +14 more
core   +1 more source

The COACH risk engine: a multistate model for predicting survival and hospitalization in patients with heart failure [PDF]

, 2012
Aims: Several models for predicting the prognosis of heart failure (HF) patients have been developed, but all of them focus on a single outcome variable, such as all-cause mortality.
Postmus, Douwe; id_orcid, Buskens, Erik; id_orcid, Harjola, Veli-Pekka,, Lewsey, James, Postmus, D., Postmus, Douwe, Hans L. Hillege, Lassus, Johan,, Hillege, Hans L.,, James Lewsey, Luttik, Marie Louise, van Veldhuisen, Dirk J.,, Harjola, V.P., Hillege, Hans L., Nieminen, M.S., Lewsey, James,, Mebazaa, Alexandre,, Veli‐Pekka Harjola, van Veldhuisen, Dirk J., Harjola, Veli-Pekka, Markku S. Nieminen, Buskens, Erik,, Luttik, Marie Louise,, Jaarsma, Tiny,, Alexandre Mebazaa, Buskens, E., Douwe Postmus, van Veldhuisen, D.J., Hillege, H.L., Johan Lassus, Buskens, Erik, Erik Buskens, Postmus, Douwe,, Marie Louise Luttik, Nieminen, Markku S., Lassus, J., Mebazaa, A., Jaarsma, Tiny, Jaarsma, T., Lassus, Johan, Dirk J. van Veldhuisen, Nieminen, Markku S.,, Luttik, M.L., Tiny Jaarsma, Lewsey, J., Mebazaa, Alexandre   +45 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Overcoming Residual Congestion in Acute Heart Failure: Defining Targets and Identifying Diuretic Responders

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Acute heart failure remains a high‐morbidity, high‐mortality syndrome with heterogeneous clinical presentations, ranging from congestion, a frequent driver of hospitalization and central therapeutic target, to hypoperfusion and cardiogenic shock in more ...
Francisco B. Alexandrino, Sílvio Nunes Augusto, W. H. Wilson Tang   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM) [PDF]

, 2008
The aim of this document is to provide practical guidelines for the diagnosis, assessment, and treatment of acute and chronic heart failure (HF). These guidelines are a development and revision of guidelines published in 1995, 1997, 2001, and 2005.
Keren A, ESC Committee for Practice Guidelines, Funck Brentano C, Dean V, Sechtem U, Silber S, Nieminen M, Widimsky P, Treatment of Acute, Strömberg A, Cohen Solal A, Hoes AW, Atar D, Dickstein K, Filippatos G, Camm J, Mebazaa A, van Veldhuisen DJ, Swedberg K, Hellemans I, Zamorano JL, McMurray JJ, De Caterina R, Kristensen SD, Task Force for Diagnosis, PRIORI, SILVIA GIULIANA, McGregor K, Poole Wilson PA, Vahanian A, Chronic Heart Failure 2008 of European Society of Cardiology, Tendera M, Ponikowski P   +31 more
core  

Weekly irinotecan in a patient with metastatic colorectal cancer on hemodialysis due to chronic renal failure [PDF]

, 2002
Background: The cytotoxic treatment of patients suffering from advanced or metastatic cancer undergoing hemodialysis due to chronic renal failure still remains a problem, since for those patients pharmacokinetic and pharmacodynamic data on most cytotoxic
Stemmler, J., Hacker, U., Schalhorn, A., Weise, A., Heinemann, Volker   +4 more
core   +1 more source

Multimorbidity in Heart Failure: Leveraging Cluster Analysis to Guide Tailored Treatment Strategies

, 2023
REVIEW PURPOSE: This review summarises key findings on treatment effects within phenotypical clusters of patients with heart failure (HF), making a distinction between patients with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF)
Savarese, G,, Asselbergs, F, Handoko, ML, Beulens, JWJ, van, de Veerdonk MC, Uijl, A,   +5 more
core   +1 more source

A systematic review on using intervention mapping to guide behavioral interventions for improving stroke patient outcomes

Frontiers in Medicine
BackgroundFunctional recovery after stroke is substantially dependent on systematic, evidence-based behavioral interventions. Intervention Mapping (IM), as a structured framework for intervention development, has demonstrated favorable outcomes across ...
Jinxian Yang, Jinxian Yang, Jianing Liu, Xiaoxia Zeng, Fan Yang, Hui Zhang, Yongxia Ding   +6 more
doaj   +1 more source