Results 181 to 190 of about 8,931,330 (313)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Two-Year Outcomes of Postoperative Spine Infection: Implant Retention and Predictors of Treatment Failure. [PDF]

Open Forum Infect Dis
Davis PJ, Hassan I, Jones TPW, Kaiser R, Stirling E, Scarborough M, Andersson MI.   +6 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Nationwide analysis of case volume and outcomes in cardiac surgery during the COVID-19 pandemicCentral Message

JTCVS Open
Jean-Luc A. Maigrot, BS, Guangjin Zhou, PhD, Siran M. Koroukian, PhD, Aaron J. Weiss, MD, PhD, A. Marc Gillinov, MD, Faisal Bakaeen, MD, Lars G. Svensson, MD, PhD, Edward G. Soltesz, MD, MPH   +7 more
doaj   +1 more source

HIV treatment failure in tertiary care: clinical epidemiology and preliminary mechanistic characterisation. [PDF]

Front Public Health
Asaga PM, Kroeger A, Omilabu S, Airiohuodion PE, Oragwa A, Buba D, Anyaike C.   +6 more
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

New perspectives in the definition and classification of acute-on-chronic liver failure

Chinese Medical Journal
Manman Xu, Yu Chen, Yanjie Yin
doaj   +1 more source

Modelling the Effects of Treatment Failure on the Minor Outbreak Duration for Carrier-Related Infectious Disease. [PDF]

Epidemiologia (Basel)
Voottipruex P, Patanarapeelert N, Patanarapeelert K.   +2 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Hemodialysis vascular access infections: epidemiology and risk factors for treatment failure. [PDF]

Korean J Intern Med
Yu SN, Lee E, Park SY, Cho OH, Yun S, Kim T, Kang MS, Baek YJ, Jung J, Kim TH.   +9 more
europepmc   +1 more source