Results 191 to 200 of about 10,822,491 (313)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Africa cannot afford to wait for malaria treatment failure. [PDF]

Malariaworld J
Pindolia D, Martinez-Vega R, Uzakbayeva G, Ishengoma D, Ngou O, Gosling R.   +5 more
europepmc   +1 more source

Nationwide analysis of case volume and outcomes in cardiac surgery during the COVID-19 pandemicCentral Message

JTCVS Open
Jean-Luc A. Maigrot, BS, Guangjin Zhou, PhD, Siran M. Koroukian, PhD, Aaron J. Weiss, MD, PhD, A. Marc Gillinov, MD, Faisal Bakaeen, MD, Lars G. Svensson, MD, PhD, Edward G. Soltesz, MD, MPH   +7 more
doaj   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Slowing the spread of treatment failure to artemisinin-based combination therapies in Uganda. [PDF]

Nat Commun
Nguyen TD, Zupko RJ, Conrad MD, Rukundo GB, Farinha CC, Asua VD, Tran KT, Grace DM, Rosenthal PJ, Agaba BB, Kamya MR, Opigo J, Boni MF.   +12 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Early Treatment Failure in Patients Receiving Ciltacabtagene-Autoleucel for Relapsed/Refractory Multiple Myeloma. [PDF]

Am J Hematol
Lim KJC, Kumar S, Parrondo R, Chhabra S, Tan M, Dooley K, Corraes AMS, Gertz M, Hwa L, Stephens H, Kapoor P, Kourelis T, Warsame R, Cook J, Binder M, Abdallah N, Bergsagel PL, Yadav U, Wiedmeier-Nutor JE, Geyer S, Rajkumar SV, Ailawadhi S, Fonseca R, Lin Y, Zanwar S.   +24 more
europepmc   +1 more source

New perspectives in the definition and classification of acute-on-chronic liver failure

Chinese Medical Journal
Manman Xu, Yu Chen, Yanjie Yin
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Development and validation of an interpretable machine-learning model for predicting treatment failure in severe trauma patients. [PDF]

Front Med (Lausanne)
Shi Q, Liu Y, Shen J, Yin F, Qiao Z, Shen X, Zhou J, Xu D, Zhang T, Xu C.   +9 more
europepmc   +1 more source