Results 41 to 50 of about 4,239,494 (310)

The hepatoadrenal syndrome: A common yet unrecognized clinical condition [PDF]

, 2005
Objective: Adrenal failure is common in critically ill patients, particularly those with sepsis. As liver failure and sepsis are both associated with increased circulating levels of endotoxin and proinflammatory mediators and reduced levels of apoprotein-
Acton, Ali, Annane, Annane, Baranova, Beishuizen, Borkowski, Calco, Cicognani, Cooper, Darlington, Davies, de la Llera-Moya, Dimopoulou, Eisenberg, Ettinger, Gordon, Hamrahian, Harry, Hinshaw, Jaattela, Kilger, Liu, Liu, Liu, Liu, Loriaux, Marik, Marik, Marik, Marik, Marik, McDonald, Melby, Miyata, Molijn, Molijn, Mookerjee, Paul E. Marik, Rasaratnam, Rivers, Scammell, Singh, Sun, Thomas E. Starzl, Timothy Gayowski, van der Voort, van Leeuwen, Vishnyakova, Yaguchi, Yokoyama, Yokoyama   +51 more
core   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Increased INR Values Predict Accelerating Deterioration and High Short-Term Mortality Among Patients Hospitalized With Cirrhosis or Advanced Fibrosis

Frontiers in Medicine, 2021
Background and Objective: An increase in the international normalized ratio (INR) is associated with increased mortality in patients with cirrhosis and other chronic liver diseases, while little is known about the quantitative relationship.
Ying Wang, Ying Wang, Fuchen Dong, Fuchen Dong, Shuning Sun, Shuning Sun, Xianbo Wang, Xianbo Wang, Xin Zheng, Xin Zheng, Yan Huang, Yan Huang, Beiling Li, Beiling Li, Yanhang Gao, Yanhang Gao, Zhiping Qian, Zhiping Qian, Feng Liu, Feng Liu, Xiaobo Lu, Xiaobo Lu, Junping Liu, Junping Liu, Haotang Ren, Haotang Ren, Yubao Zheng, Yubao Zheng, Huadong Yan, Huadong Yan, Guohong Deng, Guohong Deng, Liang Qiao, Liang Qiao, Yan Zhang, Yan Zhang, Wenyi Gu, Wenyi Gu, Xiaomei Xiang, Xiaomei Xiang, Yi Zhou, Yi Zhou, Baoyan Xu, Baoyan Xu, Yixin Hou, Yixin Hou, Qun Zhang, Qun Zhang, Yan Xiong, Yan Xiong, Congcong Zou, Congcong Zou, Jun Chen, Jun Chen, Zebing Huang, Zebing Huang, Xiuhua Jiang, Xiuhua Jiang, Tingting Qi, Tingting Qi, Sen Luo, Sen Luo, Yuanyuan Chen, Yuanyuan Chen, Na Gao, Na Gao, Chunyan Liu, Chunyan Liu, Wei Yuan, Wei Yuan, Xue Mei, Xue Mei, Jing Li, Jing Li, Tao Li, Tao Li, Rongjiong Zheng, Rongjiong Zheng, Xinyi Zhou, Xinyi Zhou, Weituo Zhang, Weituo Zhang, Hai Li, Hai Li, Zhongji Meng, Zhongji Meng   +85 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Tacrolimus-Induced Thrombotic Microangiopathy in Orthotopic Heart Transplant Patients

JACC: Case Reports
Background: Thrombotic microangiopathy (TMA) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and organ damage from microvascular injury.
Faysal Massad, MD, Tess Calcagno, MD, PharmD, Rochell Issa, MD, Kristen Tomaszewski, MD, Jennifer Reese, MSN, CNP, Randall C. Starling, MD, MPH, Andres Carmona Rubio, MD, Arianne Agdamag, MD   +7 more
doaj   +1 more source

Kuhuang injection exerts a protective effect by activating PPAR-γ in an in vitro model of chlorpromazine-induced cholestatic liver injury constructed by tissue engineering

Pharmaceutical Biology, 2022
Context Kuhuang (KH) injection is a widely used anticholestatic drug in the clinic and the mechanisms are still unclear.Objective This study uses a new 3D tissue-engineered (TE) liver platform to study the ability of kuhuang to ameliorate liver injury ...
Qiao Wu, Zhongping Duan, Long Huang, Zhijie Li   +3 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Estimating the causal effect of a time-varying treatment on time-to-event using structural nested failure time models

, 2003
In this paper we review an approach to estimating the causal effect of a time-varying treatment on time to some event of interest. This approach is designed for the situation where the treatment may have been repeatedly adapted to patient characteristics,
Dawid A. P., Gill R. D., Lok J. J., Robins J. M., Robins J. M., Robins J. M., Robins J. M., Robins J. M., Robins J. M., Robins J. M., Rubin D. B., Van der Laan M. J., Van der Vaart A. W.   +12 more
core   +4 more sources

The role of targeted viral load testing in diagnosing virological failure in children on antiretroviral therapy with immunological failure. [PDF]

, 2012
Objectives  To determine the improvement in positive predictive value of immunological failure criteria for identifying virological failure in HIV-infected children on antiretroviral therapy (ART) when a single targeted viral load measurement is ...
Calmy, Davies, Davies, Glencross, Jittamala, National Institutes of Health, Orrell, Rewari, Ruel, Schneider, Sigaloff, Stevens, Whiting, WHO, Wilson   +14 more
core   +2 more sources

Inhibiting Receptor of Advanced Glycation End Products Attenuates Pressure Overload-Induced Cardiac Dysfunction by Preventing Excessive Autophagy

Frontiers in Physiology, 2018
The receptor for advanced glycation end products (RAGE) is involved in heart failure (HF) by mediating diverse pathologic processes, including the promotion of inflammation and autophagy.
Wenbin Gao, Wenbin Gao, Wenbin Gao, Zheng Zhou, Zheng Zhou, Zheng Zhou, Birong Liang, Birong Liang, Birong Liang, Yusheng Huang, Yusheng Huang, Yusheng Huang, Zhongqi Yang, Zhongqi Yang, Zhongqi Yang, Yang Chen, Yang Chen, Lu Zhang, Lu Zhang, Lu Zhang, Cui Yan, Cui Yan, Cui Yan, Jiajia Wang, Jiajia Wang, Jiajia Wang, Lu Lu, Lu Lu, Lu Lu, Zhaorui Wen, Zhaorui Wen, Shaoxiang Xian, Shaoxiang Xian, Shaoxiang Xian, Lingjun Wang, Lingjun Wang, Lingjun Wang   +36 more
doaj   +1 more source