Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
IA1 microinvasive cervical adenocarcinoma in a young woman
DST, 2018 Introduction: The expansion of cytological screening programs for cervical cancer leads to an increase in the proportion of both adenocarcinomas and diagnoses in young women with reproductive intention.
Barbara Tavares +4 more
doaj
Treatment Outcomes in Black and White Children With Cancer: Results From the SEER Database and St Jude Children's Research Hospital, 1992 Through 2007 [PDF]
, 2012 Ching‐Hon Pui +20 more
openalex +1 more source
Outcomes of inpatient psychological treatments for children and adolescents with eating disorders at time of discharge: a systematic review [PDF]
, 2020 Leanna Isserlin +3 more
openalex +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Statistical inference for the mean outcome under a possibly non-unique optimal treatment strategy
, 2016 We consider challenges that arise in the estimation of the mean outcome under an optimal individualized treatment strategy defined as the treatment rule that maximizes the population mean outcome, where the candidate treatment rules are restricted to ...
Luedtke, Alexander R. +1 more
core +1 more source
Genomic correlates of clinical outcome in advanced prostate cancer
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The genomic landscape of metastatic castration-resistant prostate cancer (mCRPC) has been well-defined, but the association of genomic findings with patient clinical outcomes and with other characteristics including histology and ...
W. Abida +42 more
semanticscholar +1 more source
The current global situation for tuberculous meningitis: epidemiology, diagnostics, treatment and outcomes [PDF]
, 2019 James A. Seddon +4 more
openalex +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source