Results 171 to 180 of about 20,588,866 (381)

Orthodontics: treatment need and treatment outcome

, 1997
Promotor : Kuijpers-Jagtman, A.M. Co-promotor : Hof, M.A.
openaire   +2 more sources

Synthetic learner: model-free inference on treatments over time

, 2019
Understanding of the effect of a particular treatment or a policy pertains to many areas of interest -- ranging from political economics, marketing to health-care and personalized treatment studies.
Bradic, Jelena, Viviano, Davide
core  

Language style matching and treatment outcome in anorexia nervosa [PDF]

, 2022
Rachel Schaper, Christina Nowotny, Silke Michalek, Ulrike Schmidt, Timo Brockmeyer   +4 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patients’ preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative study

, 2020
Astrid C. Erber, Byron Arana, Afif Ben Salah, Issam Bennis, Aïcha Boukthir, María del Mar Castro, Mamoudou Cissé, Gláucia Cota, Farhad Handjani, Liliana López‐Carvajal, Kevin Marsh, Dalila Martínez Medina, Emma Plugge, Trudie Lang, Piero Olliaro   +14 more
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Clinical Outcome of Patients with Acute Periprosthetic Joint Infections Caused by Pseudomonas aeruginosa Compared to Other Gram-Negative Bacilli

Microorganisms
Pseudomonas aeruginosa is considered as more difficult to treat than other Gram-negatives in patients with acute periprosthetic joint infections (PJIs). However, clinical data to support this hypothesis are lacking.
Wai-Yan Liu, Johannes G. E. Hendriks, Robin W. T. M. van Kempen, Walter van der Weegen, Wim H. C. Rijnen, Jon H. M. Goosen, Babette C. van der Zwaard, Yvette Pronk, Wierd P. Zijlstra, Bas L. E. F. ten Have, Joris J. W. Ploegmakers, Marjan Wouthuyzen-Bakker   +11 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

CYP2C19 polymorphisms and outcomes of Escitalopram treatment in Brazilians with major depression [PDF]

, 2020
Rodrigo Bernini de Brito, Paulo César Ghedini   +1 more
openalex   +1 more source

The relationship between mandibular advancement, tongue movement, and treatment outcome in obstructive sleep apnea [PDF]

, 2022
Lauriane Jugé, Fiona L Knapman, Peter Humburg, Peter G.R. Burke, Aimee B Lowth, Liz Brown, Jane E. Butler, Danny J. Eckert, Joachim Ngiam, Kate Sutherland, Peter A. Cistulli, Lynne E. Bilston   +11 more
openalex   +1 more source