Results 221 to 230 of about 20,588,866 (381)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Determinants of patient-reported satisfaction with treatment outcome 6 months after rhinoplasty. [PDF]

open access: yesJPRAS Open
Luong KP   +4 more
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Ocrelizumab transiently alters microbiota and modulates immune response depending on treatment outcome. [PDF]

open access: yesiScience
Coufal S   +16 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Changes in Difficulties in Emotion Regulation Following Eating Disorders Treatment: Relevant Prospective Implications for Treatment Outcome. [PDF]

open access: yesNutrients
Rodrigues TF   +10 more
europepmc   +1 more source

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia.

open access: yesNew England Journal of Medicine, 2008
R. Schlenk   +13 more
semanticscholar   +1 more source

Excellent long-term outcomes of endovascular treatment in budd–chiari syndrome with hepatic veins involvement

open access: gold, 2018
Yonghua Bi   +5 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

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