Results 111 to 120 of about 18,135,245 (306)

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

AI-powered advances in type II endometrial cancer: global trends and African contexts

Frontiers in Oncology
IntroductionThe advent of artificial intelligence (AI) in oncology has opened new avenues for enhancing the diagnosis, treatment, and prognosis of type II endometrial cancers (ECs), which account for the majority of EC-related deaths globally.
Thulo Molefi, Thulo Molefi, Thulo Molefi, Lloyd Mabonga, Rodney Hull, Motshedisi Sebitloane, Zodwa Dlamini   +6 more
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Impact assessment of current knowledge gaps and mitigation strategies in clinical FLASH proton therapy through a systematic review

Frontiers in Oncology
IntroductionFollowing first clinical trials, the development of FLASH proton therapy (FLASH-PT) into a mature treatment modality is ongoing, while physical and biological conditions underlying the FLASH effect remain uncertain.
Anne H. zur Horst, Anne H. zur Horst, Steven J. M. Habraken, Steven J. M. Habraken, Marta Rovituso, Yvonne L. B. Klaver, Yvonne L. B. Klaver, Kees H. Spruijt, Mischa S. Hoogeman, Mischa S. Hoogeman   +9 more
doaj   +1 more source

The Lancet Commission on prostate cancer: planning for the surge in cases

The Lancet
Executive summary Prostate cancer is the most common cancer in men in 112 countries, and accounts for 15% of cancers. In this Commission, we report projections of prostate cancer cases in 2040 on the basis of data for demographic changes worldwide and ...
N. D. James, I. Tannock, J. N'Dow, Felix Y. Feng, S. Gillessen, Syed Adnan Ali, Blanca Trujillo, B. Al-Lazikani, Gerhardt Attard, F. Bray, Eva M Compérat, R. Eeles, O. Fatiregun, E. Grist, S. Halabi, Á. Haran, D. Herchenhorn, Michael Hofman, Mohamed Jalloh, Stacy Loeb, A. Macnair, Brandon A. Mahal, L. Mendes, M. Moghul, Caroline M. Moore, A. Morgans, M. Morris, Declan G Murphy, V. Murthy, Paul L. Nguyen, A. Padhani, Charles T A Parker, H. Rush, M. Sculpher, H. Soule, M. Sydes, D. Tilki, N. Tunariu, P. Villanti, Li-Ping Xie   +39 more
semanticscholar   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Stereotactic core ablative radiation therapy for small hypoxic tumors: impact of dosimetric approaches and consequent optimization strategy in the context of spatially fractionated radiation therapy

Frontiers in Oncology
PurposeStereotactic core ablative radiation therapy (SCART) delivers a single ablative dose core to the central hypoxic part while keeping low doses to the periphery of the tumor.
Zhengzheng Xu, Zhengzheng Xu, Salim Balik, Salim Balik, Kaley Woods, Kaley Woods, Andrew Lim, Andrew Lim, Jason C. Ye, Jason C. Ye, Eric L. Chang, Eric L. Chang, Kristopher Lyons, Lijun Ma, Lijun Ma, Zhilei Shen, Zhilei Shen, Lauren Lukas, Lauren Lukas, Hualin Zhang, Hualin Zhang   +20 more
doaj   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Optimizing linear energy transfer distribution in intensity-modulated proton therapy using the alternating direction method of multipliers

Frontiers in Oncology
PurposeThis study develop a novel linear energy transfer (LET) optimization method for intensity-modulated proton therapy (IMPT) with minimum monitor unit (MMU) constraint using the alternating direction method of multipliers (ADMM).Material and ...
Qingkun Fan, Xiaoyuan Zhang, Riao Dao, Yujia Qian, Lewei Zhao, Xiaoqiang Li, Xuanfeng Ding, Gang Liu, Gang Liu, Shuyang Dai, Shuyang Dai   +10 more
doaj   +1 more source