Results 111 to 120 of about 27,683,163 (345)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Computation and prediction of sectorial arch width and arch perimeter changes of maxillary arch by graphical method of Ramanujan’s equation for the ellipse

Clinical and Investigative Orthodontics
Purpose The assessment of space gain is a critical step in the non-extraction orthodontic treatment methods. This study aims to assess the arch width along the arch perimeter concurrent with the changes in the arch width due to expansion at the molar ...
Rishitha Gundeboina, Yamini Priyanka JS, Lekha Indukuru, Ravuru Divya, Vivek Reddy Ganugapanta, Gowri Sankar Singaraju, Prasad Mandava   +6 more
doaj   +1 more source

Manual on regional planning and development

, 1970
H.U.D. Project no. P-74. June, 1970 (as rev.).Process of Urbanization and Regionalization -- The Kansas Situation -- Types of Regions -- Sub-State Regional Delineation -- Regional Planning and Development -- Federal Assistance Programs for Regional ...

core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Comparative Dosimetric Analysis of Three Radiotherapy Fractionation Schedules in Synchronous Bilateral Breast Cancer: Evaluation of Lung and Heart Normal Tissue Complication Probability

Journal of Medical Physics
Aim: This study aims to evaluate and compare the impact of dosimetric parameters on lungs, heart, and associated normal tissue complication probability (NTCP) values among three different right (RT) prescription doses in patients with synchronous ...
Deepali Patil, Mukesh Kumar Zope, Richa Madhawi, Seema Devi, Devraj Singh   +4 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Principles of planning

The nature of planning. Essentials of planning. Comprehensive program of planning. Planning process.
Peng, George T. C.
core   +1 more source

Evaluation of dosimetric impact of Flattening Filter-Free (FFF) Photon Beams in 3D conformal radiotherapy

Cumhuriyet Science Journal, 2018
Flattening Filter Free (FFF) photon beams have beenfrequently used in radiotherapy clinical practice. This study aimed to analyzethe dosimetric quality of the FFF beams, as compared to the standard flattenedbeams (FB) for plans of treatment of three ...
Cherif Kourtelı, Fatima Benrachı
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Enhancing dosimetric practices through knowledge-based predictive models: a case study on VMAT prostate irradiation

Frontiers in Oncology
IntroductionAcquisition of dosimetric knowledge by radiation therapy planners is a protracted and complex process. This study delves into the impact of empirical predictive models based on the knowledge-based planning (KBP) methodology, aimed at ...
Ahmed Hadj Henni, Ilias Arhoun, Amine Boussetta, Walid Daou, Alexandre Marque, Alexandre Marque   +5 more
doaj   +1 more source