Results 91 to 100 of about 18,135,245 (306)

Enhancing dosimetric practices through knowledge-based predictive models: a case study on VMAT prostate irradiation

Frontiers in Oncology
IntroductionAcquisition of dosimetric knowledge by radiation therapy planners is a protracted and complex process. This study delves into the impact of empirical predictive models based on the knowledge-based planning (KBP) methodology, aimed at ...
Ahmed Hadj Henni, Ilias Arhoun, Amine Boussetta, Walid Daou, Alexandre Marque, Alexandre Marque   +5 more
doaj   +1 more source

Evaluation of an automated knowledge based treatment planning system for head and neck

Radiation Oncology, 2015
This study evaluated an automated inverse treatment planning algorithm, Pinnacle Auto-Planning (AP), and compared automatically generated plans with historical plans in a large cohort of head and neck cancer patients.
J. Krayenbuehl, I. Norton, G. Studer, M. Guckenberger   +3 more
semanticscholar   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Treatment plan evaluation for interstitial photodynamic therapy in a mouse model by Monte Carlo simulation with FullMonte

Frontiers in Physics, 2015
Monte Carlo (MC) simulation is recognized as the gold standard for biophotonic simulation, capturing all relevant physics and material properties at the perceived cost of high computing demands.
Jeffrey eCassidy, Vaughn eBetz, Lothar eLilge   +2 more
doaj   +1 more source

Knowledge-based radiation therapy (KBRT) treatment planning versus planning by experts: validation of a KBRT algorithm for prostate cancer treatment planning

Radiation Oncology, 2015
BackgroundA knowledge-based radiation therapy (KBRT) treatment planning algorithm was recently developed. The purpose of this work is to investigate how plans that are generated with the objective KBRT approach compare to those that rely on the judgment ...
Obioma Nwankwo, H. Mekdash, D. S. Sihono, F. Wenz, G. Glatting   +4 more
semanticscholar   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

The Use of Artificial Intelligence in Caries Detection: A Review

Bioengineering
Advancements in artificial intelligence (AI) have significantly impacted the field of dentistry, particularly in diagnostic imaging for caries detection.
Khalifa S. Al-Khalifa, Walaa Magdy Ahmed, Amr Ahmed Azhari, Masoumah Qaw, Rasha Alsheikh, Fatema Alqudaihi, Amal Alfaraj   +6 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Clinical Applications of Artificial Intelligence in Periodontology: A Scoping Review

Medicina
Background and Objectives: This scoping review aimed to identify and synthesize current evidence on the clinical applications of artificial intelligence (AI) in periodontology, focusing on its potential to improve diagnosis, treatment planning, and ...
Georgios S. Chatzopoulos, Vasiliki P. Koidou, Lazaros Tsalikis, Eleftherios G. Kaklamanos   +3 more
doaj   +1 more source