Results 81 to 90 of about 18,135,245 (306)

Deregulated MicroRNA-21 Expression in Monocytes from HIV-Infected Patients Contributes to Elevated IP-10 Secretion in HIV Infection

Frontiers in Immunology, 2017
Persistent activation and inflammation impair immune response and trigger disease progression in HIV infection. Emerging evidence supports the supposition that excessive production of interferon-inducible protein 10 (IP-10), a critical inflammatory ...
Xian Wu, Xian Wu, Le-Le Zhang, Le-Le Zhang, Lin-Bo Yin, Lin-Bo Yin, Ya-Jing Fu, Ya-Jing Fu, Yong-Jun Jiang, Yong-Jun Jiang, Hai-Bo Ding, Hai-Bo Ding, Zhen-Xing Chu, Zhen-Xing Chu, Hong Shang, Hong Shang, Zi-Ning Zhang, Zi-Ning Zhang   +17 more
doaj   +1 more source

Automatic treatment planning improves the clinical quality of head and neck cancer treatment plans

Clinical and Translational Radiation Oncology, 2016
Highlights • Autoplan can produce clinically better VMAT radiotherapy plans for H&N cancer.• Autoplan plans have similar target coverage with significant sparing of OAR.• With a template the TPS can automatically create better plans than manually created
C. Hansen, A. Bertelsen, I. Hazell, R. Zukauskaite, N. Gyldenkerne, J. Johansen, J. Eriksen, C. Brink   +7 more
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Characterizing and configuring motorized wedge for a new generation telecobalt machine in a treatment planning system

Journal of Medical Physics, 2007
A new generation telecobalt unit, Theratron Equinox-80, (MDS Nordion, Canada) has been evaluated. It is equipped with a single 60-degree motorized wedge (MW), four universal wedges (UW) for 150, 300, 450 and 600.
Kinhikar Rajesh, Sharma Smriti, Upreti Rituraj, Tambe Chandrashekhar, Deshpande Deepak   +4 more
doaj  

Current state of the art of regional hyperthermia treatment planning: a review

Radiation Oncology, 2015
Locoregional hyperthermia, i.e. increasing the tumor temperature to 40–45 °C using an external heating device, is a very effective radio and chemosensitizer, which significantly improves clinical outcome.
H. Kok, P. Wust, Paul R. Stauffer, Fernando Bardati, G. Rhoon, J. Crezee   +5 more
semanticscholar   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Evaluation of dosimetric impact of Flattening Filter-Free (FFF) Photon Beams in 3D conformal radiotherapy

Cumhuriyet Science Journal, 2018
Flattening Filter Free (FFF) photon beams have beenfrequently used in radiotherapy clinical practice. This study aimed to analyzethe dosimetric quality of the FFF beams, as compared to the standard flattenedbeams (FB) for plans of treatment of three ...
Cherif Kourtelı, Fatima Benrachı
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source