Results 101 to 110 of about 18,135,245 (306)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Comparative Dosimetric Analysis of Three Radiotherapy Fractionation Schedules in Synchronous Bilateral Breast Cancer: Evaluation of Lung and Heart Normal Tissue Complication Probability

Journal of Medical Physics
Aim: This study aims to evaluate and compare the impact of dosimetric parameters on lungs, heart, and associated normal tissue complication probability (NTCP) values among three different right (RT) prescription doses in patients with synchronous ...
Deepali Patil, Mukesh Kumar Zope, Richa Madhawi, Seema Devi, Devraj Singh   +4 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Computation and prediction of sectorial arch width and arch perimeter changes of maxillary arch by graphical method of Ramanujan’s equation for the ellipse

Clinical and Investigative Orthodontics
Purpose The assessment of space gain is a critical step in the non-extraction orthodontic treatment methods. This study aims to assess the arch width along the arch perimeter concurrent with the changes in the arch width due to expansion at the molar ...
Rishitha Gundeboina, Yamini Priyanka JS, Lekha Indukuru, Ravuru Divya, Vivek Reddy Ganugapanta, Gowri Sankar Singaraju, Prasad Mandava   +6 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

COMORBIDITY DIAGNOSES IN ALCOHOL DEPENDENT PATIENTS: DIFFERENCES AND DILEMMAS

Zdravniški Vestnik, 2002
Background. In the presented study we followed the diagnostic procedures of comorbidity in alcohol dependent patients of in-patient treatment. The aim of the study was to evaluate the incidence of dual/triple diagnoses with alcohol dependent patients and
Maja Rus-Makovec, Zdenka Čebašek-Travnik, Mirjana Radovanovič, Radica Ivančič, Vida Tomšič   +4 more
doaj  

Real world report: PSMA-PET/CT-guided TNM restaging and its consequences for treatment planning in prostate cancer

Frontiers in Oncology
ObjectiveThis study aimed to explore the effect of prostate-specific membrane antigen (PSMA) positron emission tomography and computed tomography (PET/CT) on clinical TNM (cTNM) staging assessment and treatment decision-making in prostate cancer ...
Han Chen, Peng Xian, Nan Liu, Yanping Song   +3 more
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source